Endometriosis is one of the most common and mysterious gynaecological diseases. Women with this diagnosis are twice as likely to face infertility and miscarriage. Endometriosis leads to a complex of structural and functional changes at all levels of the female reproductive system. One of the key mechanisms of infertility in endometriosis is implantation disorders, the pathogenesis of which remains completely unexplored. Still, it is known that many factors are involved in it, including chronic inflammation, resistance to progesterone, gametoand embryotoxic effects, changes in the receptivity of the endometrium and patterns of uterine contractions. It is important to know how these changes affect fertility since a complete under

A brief overview of cases of coronavirus infections, a history of study and a modern classif cation of coronaviruses is presented. Statistics on the prevalence of a new coronavirus infection in the Russian Federation as a whole and in the Astrakhan region in particular, as well as in a number of other countries, were considered. The historical aspect of vaccination has been analyzed, examples of the effectiveness of vaccine prophylaxis in both children and adults in relation to the new coronavirus infection are shown. Both arguments and counterarguments of the need for vaccine prophylaxis are presented, which affect the issues of pathogenesis, severity of the course of coronavirus infection, modification of the vaccine depending on the detection of new strains of coronaviruses, vector technologies that contribute to the rapid creation of a vaccine, the effectiveness of existing vaccines in Russia.The methods of combating coronavirus infection are outlined - information and educational activities carried out by volunteer doctors, the creation of test systems for multiplex PCR.

This review article presents the current understanding of the gastric microbiome. The most common microorganisms found in the stomach are described, including the representatives of Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria and Fusobacteria. The relationship of the oropharyngeal and duodenal ecotopes to the stomach is shown. The influence of various diseases such as gastritis, gastric epithelium metaplasia and gastric cancer, as well as the effect of proton pump inhibitors and probiotics on shifts in the qualitative and quantitative composition of gastric microflora is described.

Molecular characteristics of Burkholderia cepacia complex isolates isolated from Russian patients with cystic fibrosis are presented, including their clonal affiliation and carrying adaptive resistance genes The most prevalent species of Burkholderia cepacia complex recovered from cystic fibrosis patients was Burkholderia cenocepacia (83 %). Burkholderia strains displayed a high level of clonal diversity - ten sequence types were detected among examined isolates. Three new Burkholderia cenocepacia sequence types were discovered.

The growth and widespread of microorganisms with multiple resistance remain one of the most acute health problems, affecting the effectiveness of the therapy and gaining more and more medical and social significance every day. The search for potential drugs with antibacterial activity, characterized by a high degree of safety, has become relevant. This article provides data that discloses information on the toxicometric characteristics of four new substances derived from 5-(arylmethylene) hexahydropyrimidine- 2,4,6-triones with selective bactericidal and high antimycobacterial activity. The experiment was performed on nonlinear white mature mice with intragastric administration of 5-(arylmethylene) derivatives) hexahy dropyrimidine-2,4,6-triones. The conducted studies have shown that the compounds have low toxicity and can be considered promising substances for further research in the search for antimicrobial drugs.

An analysis of 234 cases of Astrakhan rickettsial fever was carried out, including 69 patients with comorbidity (main group) and 165 without concomitant diseases (comparison group). It was found that comorbidity contributes to the development of a pronounced intoxication syndrome, hemorrhagic syndrome and a prolonged course of Astrakhanrickettsial fever in comparison with individuals without comorbidity. A brighter onset of Astrakhan rickettsial fever is inherent in patients with concomitant diseases of the digestive system (OR = 3,462; CI = 1,023-11,707), thrombocytopenia with pathology of the cardiovascular (OR = 4,129; CI = 1,3-13,119) and urinary system (OR = 4,817 ; CI = 1,166-19,907), a longer febrile period when combined with comorbid diseases of the respiratory (OR = 4,413; CI = 1,171-16,628) and endocrine systems (OR = 3,972; CI = 1,037-15,207), and the maximum duration of exanthema in patients with concomitant pathology of respiratory (OR = 5,0; CI = 1,326-18,654), cardiovascular (OR = 2,455; CI = 1,090-5,532), endocrine (OR = 3,750; CI = 1,129-12,459) and urinary (OR = 5,250; CI = 1,056-26,057) system.

The objective of the study was to develop a treatment for recurrent bacterial vaginosis in patients with cervical ectopy and to estimate its efficacy. The authors conducted a prospective randomized trial including 95 patients aged 19 to 45 years old with a verified diagnosis of cervical ectopy and recurrent bacterial vaginosis. An antireccurent regimen was developed, including gynecological baths with 3 % hydrogen acetic acid, Septomyrin gel, oral ornidazole, clindamycin suppositories, and lactobacillus donation. The patients were divided into 3 groups: Group 1 of 35 was treated with the traditional treatment regimen, Group 2 of 30 was treated according to the developed antireccurent treatment regimen, Group 3 of 30 included the antireccurent treatment regimen and the conduction of radiowave destruction with elective cryodestruction of the complicated form of cervical ectopy. The treatment of recurrent bacterial vaginosis according to the antireccurent scheme allows to achieve a longer remission period as compared to the conventional method, to decrease the probability of recurrence by 60-89 % at any time interval during 9 months. In patients with complicated cervical ectopy, the combination of antireccurent treatment and radiosurgical, elective cryodestruction tends to improve the results by 2,3 times.

The variability of the nerves course was revealed using the preparation of subcutaneous neurovascular bundles within the anterolateral and anteromedial aspects of the knee, morphometric measurements of the isolated nerve structures on the prepared material; the data obtained was grouped in tables according to the identified nerves, and based on the obtained data, the vulnerability of specific nerves at various stages of arthroscopic surgical interventions was determined.

The article describes a clinical case of comprehensive medical rehabilitation of a preschool child at the second stage of routing in a multidisciplinary children's clinical hospital after suffering an extremely severe form of coronavirus infection. In the example of this clinical case, it is shown that rehabilitation measures initiated in the early stages against the background of active etiopathogenetic therapy for COVID-19, carried out at all stages of treatment, contribute to a reduction in the duration of stay in a hospital setting, a favourable outcome of the disease. The presence of severe complications from organs and systems, and a violation of hemostasis are not a contraindication to the early start of medical rehabilitation and its further implementation in the next stages. A multidisciplinary integrated approach, and a properly selected individual medical rehabilitation program make it possible to achieve the main goal of the second stage of rehabilitation routing of patients who have had COVID - the restoration of the function of all organs and systems involved in the pathological process.

The relevance of the topic is due to the lack of awareness of doctors about medulloblastoma of the cerebellum and IV ventricle, as well as the absence of symptoms that allow differentiating medulloblastoma from other tumours. Clinical observation of cerebellar medulloblastoma and cerebral ventricle IV is described over time. At the time of diagnosis, the patient was 4 years old, currently, the girl is 6 years old and 4 months old. The onset of the disease was accompanied by headache, lethargy and vomiting in the morning. About 3 months passed between the first symptoms and the diagnosis of the tumour. Complex treatment was carried out: surgical, polychemotherapy, and radiation therapy. The disease was complicated by occlusive hydrocephalus, cerebellar symptoms, mutism, swallowing disorder, and mild metastatic damage to the spinal cord. In catamnesis, despite the stabilization of clinical manifestations of the disease, the girl has an unfavourable prognosis with the possible progression of the pathological process.

The article presents a case of advanced ovarian cancer in an 18-year-old patient who underwent emergency radical surgery due to the spread of the malignant process and tumour necrosis. Attention is focused on compliance with the principle of “cancer alertness” in patients of any age with neoplasms of uterine appendages. The need for a comprehensive examination in this category of patients was noted.