РОЛЬ ФАКТОРА ДИФФЕРЕНЦИРОВКИ РОСТА-15 (GDF-15) В РЕГУЛЯЦИИ И РАЗВИТИИ ОСЛОЖНЕНИЙ БЕРЕМЕННОСТИ
https://doi.org/10.48612/agmu/2022.17.1.14.22
Аннотация
Изучено клиническое значение одного из малоизученных цитокинов - фактора дифференцировки роста -15 (GDF-15) в процессе регуляции клеточных и молекулярных процессов во время беременности. Современные исследования механизмов активации клеточных путей GDF-15 позволяют рассматривать этот белок в качестве одного из важных регуляторов метаболических процессов и иммунологической толерантности. Неоднозначные результаты исследований GDF-15 при различной патологии свидетельствуют о его сложной регуляции и многофункциональности. Высокие уровни циркуляции этого цитокина в сыворотке крови и в плаценте указывают на важное значение этого белка в реализации иммунного ответа при беременности, которое еще предстоит объяснить.
Об авторах
О. Г. Тишкова
Астраханский государственный медицинский университет
Россия
Россия
Л. В. Дикарева
Астраханский государственный медицинский университет
Россия
Россия
Е. Г. Шварев
Астраханский государственный медицинский университет
Россия
Россия
Ю. Ю. Уханова
Астраханский государственный медицинский университет
Россия
Россия
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Рецензия
Для цитирования:
Тишкова О.Г., Дикарева Л.В., Шварев Е.Г., Уханова Ю.Ю. РОЛЬ ФАКТОРА ДИФФЕРЕНЦИРОВКИ РОСТА-15 (GDF-15) В РЕГУЛЯЦИИ И РАЗВИТИИ ОСЛОЖНЕНИЙ БЕРЕМЕННОСТИ. Астраханский медицинский журнал. 2022;17(1):14-22. https://doi.org/10.48612/agmu/2022.17.1.14.22
For citation:
Tishkova O.G., Dikareva L.V., Shvarev E.G., Ukhanova Y.Yu. SCIENTIFIC REVIEWS Review article THE ROLE OF GROWTH DIFFERENTIATION FACTOR-15 (GDF-15) IN THE REGULATION AND THE DEVELOPMENT OF PREGNANCY COMPLICATIONS. Astrakhan medical journal. 2022;17(1):14-22. (In Russ.) https://doi.org/10.48612/agmu/2022.17.1.14.22
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