The current idea of the quality of life in patients with lymphoproliferative diseases is considered, methods of its evaluation are studied. Oncohematology is an actively developing field of medicine, where high-tech and effective methods of diagnosing and treating patients with the pathology of the hematopoietic system are constantly appearing. The latest approaches to the treatment of oncological diseases of the blood system make it possible to achieve the expected results in the form of an increase in life expectancy in most patients. Therefore, the study of the quality of life of cancer patients and the factors that affect it becomes very relevant. The purpose of the literature review was to analyze the problems and prospects of studying the quality of life in patients with lymphoproliferative diseases. Assessing and correcting the quality of life of such patients may contribute to improved communication between physician and patient, which in turn will lead to reduced complications and potential improvements in outcomes.

The problem of the immune response in adults and obese children to vaccination in infections, in particular in COVID-19, is highlighted. Changes in various parts of cellular and humoral immunity associated with chronic inflammation, which is accompanied by obesity, are disclosed. It has been shown that chronic inflammation in obesity can change the body's response to vaccination. Obese individuals, constituting a higher risk group for COVID-19, may give an altered immune response to SARS-COV-2 vaccination, which is expressed by a more severe course of the disease. Further research is needed to investigate post-vaccine immunity to SARS-COV-2 in obesity, taking into account the effect on vaccination of a particular person's microbiota and possible comorbid diseases.

An analysis of the longevity gene klotho, discovered in 1997 by the Japanese scientist M. Kuro- o, is presented. From that moment to the present day, the protein under study has been investigated in experimental models in animals and humans in clinical practice, including in normand pathology. The questions of the pathogenetic influence of klotho on the development of chronic kidney disease, some cardiovascular diseases and diabetes mellitus (often interrelated) - the main causes of the non-infectious pandemic of the XXI century are considered. The undoubted role of different concentrations of this protein in the progression of these diseases has been proven. The possibilities of modern laboratory diagnostics for the determination of klotho in blood and urine, available in practical health care, are indicated. The impact of some drugs that have a positive effect on increasing the concentration of the protein under study in the blood is described.

Endogenous defensins are a promising alternative in the treatment of infectious processes caused by antibiotic-resistant microflora. The effect of heat treatment on the dispersed composition of nanovisicles during the preparation of niosomal forms of defensins was considered. When analyzing the data of electron and atomic force microscopy, as well as the constructed integral and differential curves of the distribution of nios by size, the influence of the temperature effect on the value of their equivalent diameter was confirmed. Comparison of different temperature regimes of exposure to organosilicon niosomes showed that when they are heated, homogenization of the size of the vesicles occurs. With an increase in temperature, the number of niosomes less than 100 nm in diameter in the gel increased: from 48,8% at 25° C to 89,4% at 40° C. A decrease in the size of niosomes under temperature influences during their preparation increases their effectiveness against microorganisms resistant to antibiotics. The disk diffusion method has demonstrated the correlation of the size of the growth inhibition zone of antibiotic-resistant microorganisms around the discs with niosomal defensins when exposed to different temperatures: 25° C, 30° C, 35° C, 40° C.Statistical analysis has confirmed the ability to control the size of niosomes by heat to increase their antimicrobial efficacy.

The effect of quinazolin-4 (3H)-one derivatives with a guanidine substituent was studied: N- [Quinazolin-3 (4H)-yl] acetylguanidine (laboratory code VMA-13-10), N- [2- [4- oxo-3 (4H) -quinazolinyl] propionyl] guanidine (laboratory code VMA-13-15), N- [2- [2-methyl-4-oxo-3 (4H) -quinazolinyl] acetyl] guanidine (laboratory code VMA -13-16) and N- [2- [6-bromo-4-oxo-3 (4H) -quinazolinyl] acetyl] guanidine (laboratory code VMA-13-17) on the morphofunctional characteristics of peritoneal macrophages of white outbred mice under in vitro. The study is carried out on a primary culture of macrophages isolated from the peritoneal cavity of experimental animals. During a 2-hour exposure to the substances under study, their effect on the following indicators was studied: adhesive and plastic properties of macrophages, lysosomal and phagocytic activity. As a result of the studies, it was found that the most pronounced changes in the morphofunctional properties of peritoneal macrophages in experimental animals were observed when exposed to compounds under laboratory codes VMA-13-15 and VMA-13-17, manifested in an increase in lysosomal and phagocytic activity, without a significant effect on their adhesive and plastic properties, which makes these compounds promising for further in-depth study of their immunotropic properties.

The present study aimed to examine the effect of Selankheptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) and its counterpart (Pro-Gly-Pro) on the behaviour of white male rats under experimental hyperthyroidism. Materials and methods. The studies conducted on white non-linear male rats of 6-8 months of age following the existing international requirements and norms of humane treatment of animals. The animals were divided into 4 groups (n = 10): 1-control individuals; 2-animals with a model of hyperthyroidism; 3 and 4-individuals with a model of hyperthyroidism and received intraperitonealSelank (200 mcg/kg/day) and tripeptide Pro-Gly-Pro (200 mcg/kg/day) for 21 days accordingly. Experimental hyperthyroidism was formed by administration of L-thyroxine (150 mcg/kg/day) intragastrically, for 21 days. Motor activity and the severity of depressive state of white male rats were evaluated based on the study of animal behaviour in the “Porsolt” test. Results. The results of the study of the behaviour of laboratory animals in the “Porsolt” test showed that with the use of Selanca and tripeptide Pro-Gly-Pro at a dose of 200 μg/kg/day under experimental hyperthyroidism in male rats, an increase in the latent period to the first movement and passive swimming time, as well as a decrease in immobility and active swimming time. Conclusion. When studying the effect of Selank and its structural analog Pro-Gly-Pro on the behavioural responses of laboratory animals in the “Porsolt” test under experimental hyperthyroidism, it was proved that these glyproline neuropeptides have an antidepressant and psychomodulatory effect

Neonatal screening for congenital hypothyroidism is an effective method of early diagnosis. The presented observation demonstrates the importance of screening for early diagnosis, which allows to start treatment on time and prevent disability. The article considers 4 clinical cases of congenital hypothyroidism diagnosed by the results of neonatal screening. The features of the clinic of hypothyroidism in children aged one month are described. The data of laboratory and instrumental methods of research, indicators of the level of thyroid hormones before and after replacement therapy are demonstrated. The results of dispensary observation of children with congenital hypothyroidism in the first year of life are presented.