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OPIOID RECEPTORS: OPPORTUNITIES AND PROSPECTS
https://doi.org/10.17021/2020.15.3.16.23
Abstract
Opioid receptors belong to the family of G-protein coupled receptors (GPCRs), which are by far the most common class of cell membrane receptors, and are also targets of about one-third of the drugs used. Opioid receptors are widely studied due to their localization in various parts of the body (for example, in the brain, spinal cord, digestive tract, etc.), their crucial role in pain management, drug abuse. In addition to their still-invincible analgesic effects, opioid medications are accompanied by various side effects, including vomiting, nausea, constipation, the development of tolerance and addiction. Thus, over the years, significant efforts have been made to discover new drugs, aimed at reducing the disadvantages of these drugs while maintaining their therapeutic effectiveness. Despite this significant amount of work done over several years, safe and effective opioid remedies remain a mystery to the pharmaceutical industry.
About the Authors
M. I. Dmitrievskaya
Medical Academy named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
E. V. Sereda
Medical Academy named after S.I. Georgievsky of V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
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Review
For citations:
Dmitrievskaya M.I., Sereda E.V. OPIOID RECEPTORS: OPPORTUNITIES AND PROSPECTS. Astrakhan medical journal. 2020;15(3):16-23. (In Russ.) https://doi.org/10.17021/2020.15.3.16.23
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