Polymorphism of HLA System Genes at the dqb1* Locus in Patients with Pulmonary Tuberculosis in Astrakhan Region
https://doi.org/10.17021/1992-6499-2026-1-58-64
Abstract
Tuberculosis is one of the most serious global medical problems today. Since 2009, the Russian Federation has seen a positive trend in the main epidemiological indicators for tuberculosis, such as incidence and mortality. The detection and successful treatment of tuberculosis patients are essential for achieving epidemiological well-being in this disease. Objective: to study the genetic polymorphism of HLA system genes in the DQA 1* locus in patients with pulmonary tuberculosis in the Astrakhan region. Materials and methods. The polymorphism of HLA system genes in the DQA1* locus was studied in 34 patients who received inpatient treatment. The study included an analysis of the age and sex composition of the patients, clinical and radiological data, the frequency of occurrence of various DQA1* alleles, and the drug resistance of the pathogen. Results. It was found that the HLA-DQA1-0501* allele is significantly more common in patients with tuberculosis, especially in those with recurrent disease. Carriage of this allele was associated with a more severe course of tuberculosis, including extensive damage to the lung tissue, frequent formation of cavities, and bacterial excretion. In contrast, patients with alleles 0103* and 0301* did not exhibit bacterial excretion. Conclusion. It has been established that the DQA1 0501* allele can be a prognostic marker for progressive tuberculosis.
About the Authors
N. A. Stepanova
Astrakhan State Medical University
Russian Federation
Russian Federation
Natalia A. Stepanova, Dr. Sci. (Med.), Professor of the Department
Astrakhan
B. I. Kantemirova
Astrakhan State Medical University
Russian Federation
Russian Federation
Bela I. Kantemirova, Dr. Sci. (Med.), Professor, Head of the Department
Astrakhan
E. N. Streltsova
Astrakhan State Medical University
Russian Federation
Russian Federation
Elena N. Streltsova, Dr. Sci. (Med.), Professor, Head of the Department
Astrakhan
V. V. Vasilkova
Astrakhan State Medical University
Russian Federation
Russian Federation
Vera V. Vasilkova, Dr. Sci. (Med.), Associate Professor, Head of the Department
Astrakhan
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Review
For citations:
Stepanova N.A., Kantemirova B.I., Streltsova E.N., Vasilkova V.V. Polymorphism of HLA System Genes at the dqb1* Locus in Patients with Pulmonary Tuberculosis in Astrakhan Region. Astrakhan medical journal. 2026;21(1):58-64. (In Russ.) https://doi.org/10.17021/1992-6499-2026-1-58-64
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