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ADAPTATION AND HETEROGENEITY OF BURKHOLDERIA CEPACIA COMPLEX STRAINS POPULATION IN CONDITIONS OF CHRONIC INFECTION IN CYSTIC FIBROSIS
https://doi.org/10.17021/2020.15.1.65.73
Abstract
Cystic fibrosis is the most common hereditary disease, the life expectancy and prognosis of which is determined by the severity of respiratory pathology. One of the most prognostically unfavorable pathogens in this disease are bacteria Burkholderia cepacia complex. With bronchopulmonary colonization, they can lead to the development of “cepacia” - a syndrome that is one of the main causes of mortality in patients. From the beginning of colonization until its completion, a significant number of adaptive changes aimed at its preservation occur in the microbial population. One of such processes can be considered the phenomenon of heterogeneity. The review shows the experience of European researchers, reflecting the microbiological and clinical significance of this phenomenon, as well as a number of other adaptation processes. It is shown that strains isolated at the beginning and end of infection differ in their morphological and cultural properties, sensitivity to antibiotics and ultraviolet radiation, ability to adhesion and invasion, as well as the production of O-antigen and the ability to utilize iron.
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For citations:
Kondratenko O.V. ADAPTATION AND HETEROGENEITY OF BURKHOLDERIA CEPACIA COMPLEX STRAINS POPULATION IN CONDITIONS OF CHRONIC INFECTION IN CYSTIC FIBROSIS. Astrakhan medical journal. 2020;15(1):65-73. (In Russ.) https://doi.org/10.17021/2020.15.1.65.73
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