MYCOBACTERIOSIS IN PATIENTS WITH CYSTIC FIBROSIS: THE CAUSE OR EFFECT OF MICROECOLOGICAL CHANGES IN THE BRONCHOPULMONARY SYSTEM

This review article provides relevant data on the state of the microbiological biocenosis of the bronchopulmonary system in patients with cystic fibrosis. The main etiopathogenetic links of the development of the pathological process in cystic fibrosis are reflected, the main pathogens of bacterial complications are described. Besides, the characteristics of the microbial landscape of the lung tissue with the indicated congenital genetic pathology are characterized, the relationship of possible infectious complications with the existing background pathological process is shown. The role of iron as a factor is described, on the one hand, exacerbating the course of the infectious process, and on the other, allowing explaining the emerging microecological disturbances arising from mixed infections with cystic fibrosis, leading to the development of serious, often life-threatening complications. The fundamental biochemical processes that regulate the delivery of iron to microbial cells are described, as well as possible new therapeutic approaches to combat infectious complications that can further improve the prognosis of the course of the underlying disease for this group of patients, are presented.

mycobacteriosis, non-tuberculous mycobacteria, non-fermenting gram-negative bacteria, cystic fibrosis, iron, microbiological diagnosis

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