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The level of soluble IL-2 receptor in adults with chronic rhinosinusitis
https://doi.org/10.17021/1992-6499-2025-4-51-57
Abstract
Chronic rhinosinusitis is one of the most common chronic human diseases. One of the markers of activation of immunological processes of interest is the soluble IL-2 receptor (sIL-2R). An increase in the concentration of sIL-2R accompanies many inflammatory diseases, including those involving immunopathological processes. The aim of the study was to study the local production of sIL-2R in elderly and senile people with chronic rhinosinusitis. Material and research methods. Of the patients included in the study (n = 147), 4 groups were formed. The content of sIL-2R in nasal secretions was assessed using an enzyme immunoassay kit (Multiscan Accent; FineTest reagents) according to the instructions. Research results. In general, the data obtained show that sIL-2R production in the nasal secretions of elderly people is significantly higher than in the elderly (Iu 13.2[10.2;13.4] pg/ml vs Me 43[35;46] pg/ml, p = 0.014). An analysis of age-related features in patients with chronic rhinosinusitis indicates that the level of the receptor in mature patients is comparable to that in the elderly and senile, respectively (Me 32.2[28;45.5] pg/ml vs Me 72.9[57.2;79] pg/ml vs Me 79[65;99] pg/ml) and demonstrates an increase in sIL-2R production with age. Conclusion. Senile age compared with the elderly is associated with higher production of sIL-2R in the nasal cavity. The inflammatory process during exacerbation of chronic rhinosinusitis is characterized by an increase in its production, but there is no difference in the indicator between elderly and senile patients.
About the Authors
E. B. Belan
Volgograd State Medical University
Russian Federation
Russian Federation
Eleonora B. Belan, Dr. Sci. (Med.), Professor, Head of the Department,
Volgograd .
N. V. Tarasova
Volgograd State Medical University
Russian Federation
Russian Federation
Natalia V. Tarasova, Dr. Sci. (Med.), Professor, Head of the Department,
Volgograd.
M. V. Sokolova
Volgograd State Medical University
Russian Federation
Russian Federation
Maria V. Sokolova, Assistant of the Department,
Volgograd.
A. V. Gorshenin
Scientific Research Institute of Hygiene, Toxicology and Occupational Pathology of the FMBA of Russia
Russian Federation
Russian Federation
Andrey V. Gorshenin, Cand. Sci. (Med.), Head of the Laboratory,
Volgograd.
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Review
For citations:
Belan E.B., Tarasova N.V., Sokolova M.V., Gorshenin A.V. The level of soluble IL-2 receptor in adults with chronic rhinosinusitis. Astrakhan medical journal. 2025;20(4):51-57. (In Russ.) https://doi.org/10.17021/1992-6499-2025-4-51-57
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