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Morphogenesis of laboratory rat’s upper jaw in ontogenesis
https://doi.org/10.17021/1992-6499-2025-3-17-33
Abstract
The rat’s upper jaw of is a unique experimental object in biomedical research and is used to model various pathological conditions: fractures, postmenopausal osteoporosis, disorders of dentinogenesis and enamelogenesis. The rat’s upper jaw and humans differ in a number of morpho-functional aspects related to the peculiarities of nutrition and the structure of incisors in rodents. However, a comprehensive study of the processes of its development, growth and formation in rats in the experiment will contribute to further understanding of the features of its organization in humans. The purpose of the research: to analyze the existing domestic and foreign literature, to summarize and systematize the available information about the structure of the laboratory rat’s upper jaw at various stages of ontogenesis. The literature search on the subject of the presented article was conducted using the elibrary and PubMed databases, inclusive, until 09.10.2024. Literature sources were analyzed regardless of date, language and type (full text or abstract only). The presented work comprehensively examines issues related to the sources and periods of development, the macroscopic structure of the upper jaw, the structural features of the alveolar bone and its response to exogenous stimuli, the structural organization of the enamel organ, dentin, cement, pulp, periodontium, their blood supply and innervation during various periods of ontogenesis. Despite the differences in structural and functional organization of the upper jaw of humans and rats, the basic structure of their alveolar bone, dentin, enamel, periodontium and pulp has much in common.
About the Authors
V. I. Luzin
Sent Luke Lugansk State Medical University
Россия
Россия
Vladyslav I. Luzin, Dr. Sci. (Med.), Professor, Head of the Department
Lugansk
V. N. Morozov
Belgorod National Research University
Россия
Россия
Vitaliy N. Morozov, Cand. Sci. (Med.), Associate Professor
Belgorod
E. N. Morozova
Belgorod National Research University
Россия
Россия
Elena N. Morozova, Cand. Sci. (Med.), Associate Professor
Belgorod
A. V. Solin
Belgorod National Research University
Россия
Россия
Alexey V. Solin, Dr. Sci. (Med.), Associate Professor
Belgorod
N. A. Mosyagina
Sent Luke Lugansk State Medical University
Россия
Россия
Nadezhda A. Mosyagina, Assistant Professor of the Department
Lugansk
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Review
For citations:
Luzin V.I., Morozov V.N., Morozova E.N., Solin A.V., Mosyagina N.A. Morphogenesis of laboratory rat’s upper jaw in ontogenesis. Astrakhan medical journal. 2025;20(3):17-33. (In Russ.) https://doi.org/10.17021/1992-6499-2025-3-17-33
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