Microecological state of the gut after correction of stress-induced dysbiosis by peptide Thr-Lys-Pro-Arg-Pro-Gly-Pro
https://doi.org/10.17021/1992-6499-2024-3-30-37
Abstract
Stress can disrupt bidirectional communication within the framework of the microbiota-gut-brain axis, including affecting the microbiological landscape and morphofunctional state of the mucous membrane of the colon. In this work we studied the ability of the peptide Thr-Lys-Pro-Arg-Pro-Gly-Pro (tuftsin-pgp) to correct the state of stress-induced dysbiosis in doses of 80, 250 and 750 pg/kg. The increase in the specific content, frequency of occurrence and relative average value of opportunistic bacteria of control stressed animals noted in the study with a decrease in the number and proportion of obligate bacteria indicated active colonization of the mucous membrane of the colon by them. Administration of tuftsin-pgp dose-dependently changed the qualitative and quantitative composition of the studied biotope microbiota. We found out that the most pronounced positive effect on the signs of stress-induced dysbiosis was the administration of the peptide at a dose of 250 pg/kg.
About the Authors
M. S. KrivoshlykovaRussian Federation
Marina S. Krivoshlykova - Assistant, Kursk State Medical University.
Kursk
O. A. Medvedeva
Russian Federation
Ol’ga A. Medvedeva - Dr. Sci. (Biol.), Professor, Head of the Department, Kursk State Medical University.
Kursk
I. I. Bobyntsev
Russian Federation
Igor’ I. Bobyntsev - Dr. Sci. (Med.), Professor, Head of the Department, Director, Kursk State Medical University.
Kursk
A. Yu. Mukhina
Russian Federation
Aleksandra Yu. Mukhina - Cand. Sci. (Med.), Associate Professor of the Department, Senior Researcher, Kursk State Medical University.
Kursk
A. O. Vorvul’
Russian Federation
Anton O. Vorvul’ - Cand. Sci. (Med.), Assistant, Senior Researcher, Kursk State Medical University.
Kursk
A. V. Shevchenko
Russian Federation
Alina V. Shevchenko - Cand. Sci. (Med.), Associate Professor of the Department, Kursk State Medical University.
Kursk
L. A. Andreeva
Russian Federation
Lyuidmila A. Andreeva - Cand. Sci. (Chem.), Deputy Head of the Laboratory, Kurchatov Institute.
Moscow
N. F. Myasoedov
Russian Federation
Nikolay F. Myasoedov - Dr. Sci. (Chem.), Academician of RAS, Head of the Laboratory, Kurchatov Institute.
Moscow
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Supplementary files
Review
For citations:
Krivoshlykova M.S., Medvedeva O.A., Bobyntsev I.I., Mukhina A.Yu., Vorvul’ A.O., Shevchenko A.V., Andreeva L.A., Myasoedov N.F. Microecological state of the gut after correction of stress-induced dysbiosis by peptide Thr-Lys-Pro-Arg-Pro-Gly-Pro. Astrakhan medical journal. 2024;19(3):30-37. (In Russ.) https://doi.org/10.17021/1992-6499-2024-3-30-37