The role of free-radical oxidation processes in the pathogenesis of early miscarriage
https://doi.org/10.29039/1992-6499-2023-1-27-38
Abstract
Currently, despite the already known pathogenic factors and mechanisms of miscarriage, about 50 % of ones continue to be unspecified or idiopathic. In recent years, the role of oxidative stress in the pathogenesis of many diseases, including the female reproductive system and pregnancy complications, has been actively discussed.
The purpose of the review is to analyze and provide information on the role of free-radical oxidation processes in the development and course of a pregnancy, both in normal and in miscarriage, as well as on the possible use of oxidative stress biomarkers in practical medicine, in order to assess the nature of the pathological process and the effectiveness of treatment.
Understanding the processes of cell damage caused by oxidative stress can provide invaluable assistance not only in developing a personalized approach to each specific case of miscarriage, but also to expand knowledge, both scientific and clinical in this area of medicine.
Keywords
miscarriage,
oxidative stress,
reactive oxygen species,
oxidative stress biomarkers,
antioxidant system
Supporting agencies: The authors declare that there is no external funding for the exploration and analysis work
About the Authors
O. G. Tishkova
Astrakhan State Medical University
Russian Federation
Russian Federation
Olga G. Tishkova, Cand. Sci. (Med.), Associate Professor
Astrakhan
L. V. Dikareva
Astrakhan State Medical University
Russian Federation
Russian Federation
Lyudmila V. Dikareva, Dr. Sci. (Med.), Professor, Head of the Department
Astrakhan
D. D. Tepliy
Astrakhan State University
Russian Federation
Russian Federation
Dmitry D. Tepliy, Dr. Sci. (Biol.), Senior Researcher
Astrakhan
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For citations:
Tishkova O.G., Dikareva L.V., Tepliy D.D. The role of free-radical oxidation processes in the pathogenesis of early miscarriage. Astrakhan medical journal. 2023;18(1):27-38. (In Russ.) https://doi.org/10.29039/1992-6499-2023-1-27-38
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