INTRANASAL ADMINISTRATION OF BACTERIOPHAGE STAPHYLOCOCCUS PHAGE CH1 IN INDIVIDUAL AND GROUP HOUSING OF MONKEYS
https://doi.org/10.48612/agmu/2022.17.4.117.125
Abstract
Antibiotic resistance of pathogens of infectious diseases, such as Staphylococcus aureus, leads to the need to search for additional means of combating bacterial infections, which can be bacteriophages. An individual and family group of Macaca mulatta (rhesus monkeys) with confirmed carriage of S. aureus received purified Staphylococcus phage CH1 phagolysates intranasally. The presence of bacteria and bacteriophage in nasal scrapings of monkeys was determined. The study showed the effectiveness of bacteriophage CH1 as a drug for the treatment of infection caused by bacteria S. aureus, its high lytic activity, as well as the ability to persist for a long time in the body of animals.
Supporting agencies: The authors declare that there is no external funding for the exploration and analysis work.
About the Authors
E. V. Cherkachina
Research Institute of Medical Primatology
Russian Federation
Russian Federation
Elena V. Cherkachina, Post-graduate Student, Veterinarian
Sochi, Adlersky district, Vesyoloye
A. V. Demerchyan
Research Institute of Medical Primatology
Russian Federation
Russian Federation
Alvard V. Demerchyan, Researcher
Sochi, Adlersky district, Vesyoloye
V. I. Polyakova
Research Institute of Medical Primatology
Russian Federation
Russian Federation
Veronica I. Polyakova, Junior Researcher
Sochi, Adlersky district, Vesyoloye
I. A. Kiseleva
Gabrichevsky Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
Irina A. Kiseleva, Cand. Sci. (Biol.), Leading Researcher
Moscow
A. D. Daudova
Astrakhan State Medical University
Russian Federation
Russian Federation
Adilya D. Daudova, Cand. Sci. (Med.), Associate Professor, Associate Professor of Department
Astrakhan
O. V. Rubalsky
Astrakhan State Medical University
Russian Federation
Russian Federation
Oleg V. Rubalsky, Dr. Sci. (Med.), Professor, Head of Department
Astrakhan
I. M. Arshba
Research Institute of Medical Primatology
Russian Federation
Russian Federation
Ilona M. Arshba, Cand. Sci. (Biol.), Acting Head of Laboratory, Leading Researcher
Sochi
M. A. Samotrueva
Astrakhan State Medical University
Russian Federation
Russian Federation
Marina A. Samotrueva, Dr. Sci. (Med.), Professor, Head of Department
Astrakhan
O. A. Bashkina
Astrakhan State Medical University
Russian Federation
Russian Federation
Olga A. Bashkina, Dr. Sci. (Med.), Professor, Head of Department
Astrakhan
E. O. Rubalskii
Gabrichevsky Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
Evgenii O. Rubalskii, Cand. Sci. (Biol.), Leading Researcher
Moscow
S. V. Orlov
Research Institute of Medical Primatology
Russian Federation
Russian Federation
Sergei V. Orlov, Dr. Sci. (Med.), Professor, Corresponding Member of RAS, Director
Sochi, Adlersky district, Vesyoloye
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Review
For citations:
Cherkachina E.V., Demerchyan A.V., Polyakova V.I., Kiseleva I.A., Daudova A.D., Rubalsky O.V., Arshba I.M., Samotrueva M.A., Bashkina O.A., Rubalskii E.O., Orlov S.V. INTRANASAL ADMINISTRATION OF BACTERIOPHAGE STAPHYLOCOCCUS PHAGE CH1 IN INDIVIDUAL AND GROUP HOUSING OF MONKEYS. Astrakhan medical journal. 2022;17(4):117-125. (In Russ.) https://doi.org/10.48612/agmu/2022.17.4.117.125
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