Preview

Astrakhan medical journal

Advanced search
Open Access Open Access  Restricted Access Subscription Access

OBSERVATIONS FROM PRACTICE Original article CATAMNESIS OF MEDULLOBLASTOMA OF THE CEREBELLUM AND IV VENTRICLE OF THE BRAIN IN A GIRL 6 YEARS

https://doi.org/10.48612/agmu/2022.17.2.102.108

Abstract

The relevance of the topic is due to the lack of awareness of doctors about medulloblastoma of the cerebellum and IV ventricle, as well as the absence of symptoms that allow differentiating medulloblastoma from other tumours. Clinical observation of cerebellar medulloblastoma and cerebral ventricle IV is described over time. At the time of diagnosis, the patient was 4 years old, currently, the girl is 6 years old and 4 months old. The onset of the disease was accompanied by headache, lethargy and vomiting in the morning. About 3 months passed between the first symptoms and the diagnosis of the tumour. Complex treatment was carried out: surgical, polychemotherapy, and radiation therapy. The disease was complicated by occlusive hydrocephalus, cerebellar symptoms, mutism, swallowing disorder, and mild metastatic damage to the spinal cord. In catamnesis, despite the stabilization of clinical manifestations of the disease, the girl has an unfavourable prognosis with the possible progression of the pathological process.

About the Authors

T. N. Buchkova
Saratov State Medical University named after V.I. Razumovsky
Russian Federation


N. I. Zryachkin
Saratov State Medical University named after V.I. Razumovsky
Russian Federation


G. M. Andryakova
Saratov State Medical University named after V.I. Razumovsky
Russian Federation


References

1. Rossi A., Caracciolo V., Russo G., Reiss K., Giordano A. Medulloblastoma: from molecular pathology to therapy // Clinical cancer research. 2008. Vol. 14, no. 4. P. 971-976.

2. Massimino M., Giangaspero F., Garrè M. L., Gandola L., Poggi G., Biassoni V., Gatta G., Rutkowski S. Childhood medulloblastoma // Critical Reviews in Oncology/Hematology. 2011. Vol. 79, no.1. P. 65-83.

3. Gerber N. U., von Hoff K., von Bueren A. O., Treulieb W., Deinlein F., Benesch M., Zwiner I., Soerensen N., Warmuth-Metz M., Pietsch T., Mittler U., Kuhl J., Kortmann R.-D., Grotzer M. A., Rutkowski S. A long duration of the prediagnostic symptomatic interval is not associated with an unfavourable prognosis in childhood medulloblastoma // European journal of cancer. 2012. Vol. 48, no. 13. P. 2028-2036.

4. Матуев, К. Б. Опухоли головного мозга у детей грудного возраста: автореф. дис. докторара.мед. наук. M., 2014. 48 с.

5. Tonn J. C., Westphal M., Rutka J. T., Grossman S. A. Neuro-Oncology of CNS Tumors. Springer Berlin Heidelberg, 2006. 706 p.

6. Хачатрян В. А., Улитин А. Ю., Кумирова Э. В., Желудкова О. Г., Румянцев А. Г., Ким А. В., Самочерных К. А., А. Р. Тадевосян, Дон О. А., Солтан П. С., Пальцев А. А. Медуллобластома у детей (обзор литературы). Ч. 2: Комплексное лечение // Нейрохирургия и неврология детского возраста. 2014. Т. 40, № 2. С. 68-80.

7. Ashley D. M., Merchant T. E., Strother D., Zhou T., Duffner P., Burger P. C., Miller D. C., Lyon N., Bonner M. J., Msall M., Buxton A., Geyer R., Kun L. E., Coleman L., Pollack I. F. Induction chemotherapy and conformal radiation therapy for very young children with nonmetastatic medulloblastoma: Children’s Oncology Group study P9934 // Journal of clinical oncology. 2012. Vol. 30, no. 26. P. 3181-3186. doi: 10.1200/JTO.2010.34.4341.

8. Gerber N. U., Mynarek M., von Hoff K., Friedrich C., Resch A., Rutkowski S. Recent developments and current concepts in medulloblastoma // Cancer Treatment Reviews. 2014. Vol. 40, no. 3. P. 356-365.

9. Лехечка М., Лааксо А., Кивелев Ю. В., Хернесниеми Ю. Микронейрохирургия Хельсинки: Приемы и советы от профессора Хернесниеми. СПб.: Б. Браун Медикал, 2012. 344 с.

10. Lannering B., Rutkowski S., Doz F., Pizer B., Gustafsson G., Navajas A., Massimino M., Reddingius R., Benes M., Currie C., Taylor R., Gandola L., Bjoerk-Eriksson T., Giralt J., Oldenburger F., Pietsch T., Figarella-Branger D., Robson K., Forni M., Clifford S. K., Warmuth-Metz M., von Hoff K., Faldum A., Mosseri V., Kortmann R. Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standardrisk medulloblastoma: results from the randomized multicenter HIT-SIOP PNET 4 trial // Journal of clinical oncology. 2012. Vol. 30, no. 26. P. 3187-3193.

11. Rutkowski S., von Hoff K., Emser A., Zwiener I., Pietsch T., Figarella-Branger D., Giangaspero F., Ellison D., Garre M.-L., Biassoni V., Grandi R., Finlay J. L., Dhall G., Raquin M.A., Grill J. Survival and prognostic factors of early childhood medulloblastoma: an international metaanalysis // Journal of clinical oncology. 2010. Vol. 28, no. 33. P. 4961-4968.

12. Pizer B., Donachie P. H., Robinson K., Taylor R. E., Michalski A., Punt J., Ellison D. W., Picton S. Treatment of recurrent central nervous system primitive neuroectodermaltumours in children and adolescents: results of a Children’s Cancer and Leukaemia Group study // European journal of cancer. 2011. Vol. 47, no. 9. P. 1389-1397.

13. Dunkel I. J., Gardner S. L., Garvin Jr J. H., Goldman S., Shi W., Finlay J. L. Highdose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma // Neuro-Oncology. 2010. Vol. 12, no. 3. P. 297-303.

14. von Hoff K., Hinke B., Gerber N. U., Deinlein F., Mittler U., Urban C., Benes M., Warmuth-Metz M., Soerensen N., Zwiner I., Goette H., Schlegel P. G., Pietsch T., Kortmann R. D., Kuhl J., Rutkowski S. Longterm outcome and clinical prognostic factors in children with MB treated in the prospective randomized multicentre trial HIT’91 // European journal of cancer. 2009. Vol. 45, no. 7. P. 1209-1217.

15. Wong S. F., Mak G., Rosenthal M. A., Cher L., Gan H. K. Local perspective on a rare brain tumour: adult medulloblastoma // Internal medicine journal. 2013. Vol. 43, no. 5. P. 567-572.

16. Packer R. J.,Zhou T., Holmes E., Vezina G., Gajjar A. Survival and secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy: results of Children's Oncology Group trial A9961 // Neuro-Oncology. 2013. Vol. 15, no. 1. P. 97-103.

17. Duffner P. K. Risk factors for cognitive decline in children treated for brain tumors // European journal of paediatric neurology. 2010. Vol. 14, no. 2. P. 106-115.

18. Embry L., Annett R. D., Kunin-Batson A., Patel S. K., Sands S., Reaman G., Noll R. B. Implementation of multisite neurocognitive assessments within a pediatric cooperative group: can it be done? // Pediatr Blood Cancer. 2012. Vol. 59, no. 3. P. 536-539.

19. Шмелева О. О., Хачатрян В. А., Самочерных К. А., Ким А. В., Дон О. А. Синдром мозжечкового мутизма у детей после удаления опухолей задней черепной ямки (клинические случаи и обзор литературы) // Нейрохирургия и неврология детского возраста. 2012. № 2-3. С. 70-81.

20. Gudrunardottir T., Sehested A., Juhler M., Schmiegelow K. Cerebellar mutism: review of the literature // Child's nervous system. 2011. Vol. 27, no. 3. P. 355-363.

21. Frange P., Alapetite C., Gaboriaud G., Bours D., Zucker J. M., Zerah M., Brisse H., Chevignard M., Mosseri V., Bouffet E., Doz F. From childhood to adulthood: longterm outcome of medulloblastoma patients. The Institut Curie experience (1980-2000) // Journal of neurooncology. 2009. Vol. 95, no. 2. P. 271-279. doi: 10.1007/s11060-009-9927-z.


Review

For citations:


Buchkova T.N., Zryachkin N.I., Andryakova G.M. OBSERVATIONS FROM PRACTICE Original article CATAMNESIS OF MEDULLOBLASTOMA OF THE CEREBELLUM AND IV VENTRICLE OF THE BRAIN IN A GIRL 6 YEARS. Astrakhan medical journal. 2022;17(2):102-108. (In Russ.) https://doi.org/10.48612/agmu/2022.17.2.102.108

Views: 152


ISSN 1992-6499 (Print)