SCIENTIFIC REVIEWS Review article GASTRIC MICROBIOME DIVERSITY IN HEALTH AND DISEASE
https://doi.org/10.48612/agmu/2022.17.2.21.28
Abstract
This review article presents the current understanding of the gastric microbiome. The most common microorganisms found in the stomach are described, including the representatives of Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria and Fusobacteria. The relationship of the oropharyngeal and duodenal ecotopes to the stomach is shown. The influence of various diseases such as gastritis, gastric epithelium metaplasia and gastric cancer, as well as the effect of proton pump inhibitors and probiotics on shifts in the qualitative and quantitative composition of gastric microflora is described.
About the Authors
V. S. Tereshchenko
Samara State Medical University
Russian Federation
Russian Federation
A. V. Zhestkov
Samara State Medical University
Russian Federation
Russian Federation
E. A. Zheleznova
Samara State Medical University
Russian Federation
Russian Federation
T. A. Savinova
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
A. V. Lyamin
Samara State Medical University
Russian Federation
Russian Federation
References
1. Gill S. R., Pop M., Deboy R. T., Eckburg P. B., Turnbaugh P. J., Samuel B. S., Gordon J. I., Relman D. A., Fraser Liggett C. M., Nelson K. E. Metagenomic Analysis of the Human Distal Gut Microbiome // Science. 2006. Vol. 312, no. 5778. P. 1355-1359.
2. Swidsinski A., Loening Baucke V., Schulz S., Manowsky J., Verstraelen H., Swidsinski S. Functional anatomy of the colonic bioreactor: Impact of antibiotics and Saccharomyces boulardii on bacterial composition in human fecal cylinders // Systematic and applied microbiology. 2016. Vol. 39, no. 1. P. 67-75.
3. Nardone G., Compare D. The human gastric microbiota: Is it time to rethink the pathogenesis of stomach diseases // United European gastroenterology journal. 2015. Vol. 3, no. 3. P. 255-260.
4. Yang I., Nell S., Suerbaum S. Survival in hostile territory: the microbiota of the stomach // FEMS microbiology reviews. 2013. Vol. 37, no. 5. P. 736-761.
5. Zwolińska Wcisło M., Budak A, Trojanowska D, Bogdał J, Stachura J. Fungal colonization of the stomach and its clinical relevance // Mycoses. 1998. Vol. 41, no. 7-8. P. 327-334.
6. von Rosenvinge E. C., Song Y., White J. R., Maddox C., Blanchard T., Fricke W. F. Immune status, antibiotic medication and pH are associated with changes in the stomach fluid microbiota // The ISME journal. 2013. Vol. 7, no. 7. P. 1354-1366.
7. Siavoshi F., Saniee P. Vacuoles of Candida yeast as a specialized niche for Helicobacter pylori // World journal of gastroenterology. 2014. Vol. 20, no. 18. P. 5263-5273.
8. Noto J. M., Peek Jr. R. M. The gastric microbiome, its interaction with Helicobacter pylori, and its potential role in the progression to stomach cancer // PLoS pathogens. 2017. Vol. 13, no. 10. e1006573.
9. Bik E. M., Eckburg P. B., Gill S. R., Nelson K. E., Purdom E. A., Francois F., Perez-Perez G., Blaser M. J., Relman D. A. Molecular analysis of the bacterial microbiota in the human stomach // Proceedings of the National Academy of Sciences of the United States of America. 2006. Vol. 103, no. 3. P. 732-737.
10. Bravo D., Hoare A., Soto C., Valenzuela M. A., Quest A. F. Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects // World journal of gastroenterology. 2018. Vol. 24, no. 28. P. 3071-3089.
11. Hooi J. K. Y., Lai W. Y., Ng W. K., Suen M. M. Y., Underwood F. E., Tanyingoh D., Malfertheiner P., Graham D. Y., Wong V. W. S., Wu J. C. Y., Chan F. K. L., Sung J. J. Y., Kaplan G. G., Ng S. C. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis // Gastroenterology. 2017. Vol. 153, no. 2. P. 420-429.
12. Wang L. L., Yu X. J., Zhan S. H., Jia S. J., Tian Z. B., Dong Q. J. Participation of microbiota in the development of gastric cancer // World journal of gastroenterology. 2014. Vol. 20, no. 17. P. 4948-4952
13. Llorca L., Pérez Pérez G., Urruzuno P., Martinez M. J., Iizumi T., Gao Z., Sohn J., Chung J., Cox L., Simón Soro A., Mira A., Alarcón T. Characterization of the Gastric Microbiota in a Pediatric Population According to Helicobacter pylori Status // The Pediatric infectious disease journal. 2017. Vol. 36, no. 2. P. 173-178.
14. Rajilić Stojanović M., de Vos W. M. The first 1000 cultured species of the human gastrointestinal microbiota // FEMS microbiology reviews. 2014. Vol. 38, no. 5. P. 996-1047.
15. Rajilic Stojanovic M., Figueiredo C., Smet A., Hansen R., Kupcinskas J., Rokkas T., Andersen L., Machado J. C., Ianiro G., Gasbarrini A., Leja M., Gisbert J. P., Hold G. L. Systematic review: gastric microbiota in health and disease // Alimentary pharmacology & therapeutics. 2020. Vol. 51, no. 6. P. 582-602.
16. Bassis C. M., Erb-Downward J. R., Dickson R. P., Freeman C. M., Schmidt T. M., Young V. B., Beck J. M., Curtis J. L., Huffnagle G. B. Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals // MBio. 2015. Vol. 6, no. 2. e00037.
17. Schulz C., Schütte K., Koch N., Vilchez Vargas R., Wos-Oxley M. L., Oxley A. P. A., Vital M., Malfertheiner P., Pieper D. H. The active bacterial assemblages of the upper GI tract in individuals with and without Helicobacter infection // Gut. 2018. Vol. 67, no. 2. P. 216-225.
18. Walker M. M., Talley N. J. Review article: bacteria and pathogenesis of disease in the upper gastrointestinal tract beyond the era of Helicobacter pylori // Alimentary pharmacology & therapeutics. 2014. Vol. 39, no. 8. P. 767-779.
19. Gall A., Fero J., McCoy C., Claywell B. C., Sanchez C. A., Blount P. L., Li X., Vaughan T. L., Matsen F. A., Reid B. J., Salama N. R. Bacterial Composition of the Human Upper Gastrointestinal Tract Microbiome Is Dynamic and Associated with Genomic Instability in a Barrett’s Esophagus Cohort // PLoS One. 2015. Vol. 10, no. 6. e0129055
20. Amir I., Konikoff F. M., Oppenheim M., Gophna U., Half E. E. Gastric microbiota is altered in oesophagitis and Barrett’s oesophagus and further modified by proton pump inhibitors // Environmental microbiology. 2014. Vol. 16, no. 9. P. 2905-2914.
21. Nasrollahzadeh D., Malekzadeh R., Ploner A., Shakeri R., Sotoudeh M., Fahimi S., Nasseri-Moghaddam S., Variations of gastric corpus microbiota are associated with early esophageal squamous cell carcinoma and squamous dysplasia // Scientific reports. 2015. Vol. 5, Article number 8820.
22. Chen X., Xia C., Li Q., Jin L., Zheng L., Wu Z.Comparisons Between Bacterial Communities in Mucosa in Patients With Gastric Antrum Ulcer and a Duodenal Ulcer // Frontiers in cellular and infection microbiology. 2018. Vol. 8, P. 126.
23. Babu S. D., Jayanthi V., Devaraj N., Reis C. A., Devaraj H. Expression profile of mucins (MUC2, MUC5AC and MUC6) in Helicobacter pylori infected preneoplastic and neoplastic human gastric epithelium // Molecular cancer. 2006. Vol. 5. P. 10.
24. Eun C. S., Kim B. K., Han D. S., Kim S. Y., Kim K. M., Choi B. Y., Song K. S., Kim Y. S., Kim J. F. Differences in gastric mucosal microbiota profiling in patients with chronic gastritis, intestinal metaplasia, and gastric cancer using pyrosequencing methods // Helicobacter. 2014. Vol. 19, no. 6. P. 407-416.
25. Ferreira R. M., Pereira Marques J., Pinto-Ribeiro I., Costa J. L., Carneiro F., Machado J. C., Figueiredo C. Gastric microbial community profiling reveals a dysbiotic cancer associated microbiota // Gut. 2018. Vol. 67, no. 2. P. 226-236.
26. Jo H. J., Kim J., Kim N., Park J. H., Nam R. H., Seok Y. J., Kim Y. R., Kim J. S., Kim J. M., Kim J. M., Lee D. H., Jung H. C. Analysis of Gastric Microbiota by Pyrosequencing: Minor Role of Bacteria Other Than Helicobacter pylori in the Gastric Carcinogenesis // Helicobacter. 2016. Vol. 21, no. 5. P. 364-374.
27. Coker O. O., Dai Z., Nie Y., Zhao G., Cao L., Nakatsu G., Wu W. K., Wong S. H., Chen Z., Sung J. J. Y., Yu J. Mucosal microbiome dysbiosis in gastric carcinogenesis // Gut. 2018. Vol. 67, no. 6. P. 1024-1032.
28. Yang I., Woltemate S., Piazuelo M. B., Bravo L. E., Yepez M. C., Romero-Gallo J., Delgado A. G., Wilson K. T., Peek R. M., Correa P., Josenhans C., Fox J. G., Suerbaum S. Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia // Scientific reports. 2016. Vol. 6. Article number: 18594.
29. Maseda D., Ricciotti E. NSAID-Gut Microbiota Interactions // Frontiers in pharmacology. 2020. Vol. 11. Article number: 1153.
30. Parsons B. N., Ijaz U. Z., D'Amore R., Burkitt M. D., Eccles R., Lenzi L., Duckworth C. A., Moore A. R., Tiszlavicz L., Varro A., Hall N., Pritchard D. M.Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use // PLoS pathogens, 2017. Vol. 13, no. 11. P. e1006653.
31. Paroni Sterbini F., Palladini A., Masucci L., Cannistraci C. V., Pastorino R., Ianiro G., Bugli F., Martini C., Ricciardi W., Gasbarrini A., Sanguinetti M., Cammarota G., Posteraro B. Effects of Proton Pump Inhibitors on the Gastric Mucosa-Associated Microbiota in Dyspeptic Patients // Applied and environmental microbiology, 2016. Vol. 82, no. 22. P. 6633-6644.
32. Mailhe M., Ricaboni D., Vitton V., Gonzalez J. M., Bachar D., Dubourg G., Cadoret F., Robert C., Delerce J., Levasseur A., Fournier P. E., Angelakis E., Lagier J. C., Raoult D. Repertoire of the gut microbiota from stomach to colon using culturomics and next generation sequencing // BMC microbiology, 2018. Vol. 18, no. 1. Article number: 157.
33. Igarashi M., Nakae H., Matsuoka T., Takahashi S., Hisada T., Tomita J., Koga Y. Alteration in the gastric microbiota and its restoration by probiotics in patients with functional dyspepsia // BMJ open gastroenterology, 2017. Vol. 4, no. 1. e000144.
Review
For citations:
Tereshchenko V.S., Zhestkov A.V., Zheleznova E.A., Savinova T.A., Lyamin A.V. SCIENTIFIC REVIEWS Review article GASTRIC MICROBIOME DIVERSITY IN HEALTH AND DISEASE. Astrakhan medical journal. 2022;17(2):21-28. (In Russ.) https://doi.org/10.48612/agmu/2022.17.2.21.28
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