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Features of the influence of human chorionic gonadotropin on the course of extrasystolic arrhythmia in pregnant women
https://doi.org/10.17021/1992-6499-2025-2-92-104
Abstract
Evaluation of a relationship of extrasystole with human chorionic gonadotropin is one of the poorly studied issues of obstetrics and cardiology.
A purpose of this work is to study an effect of human chorionic gonadotropin on course of extrasystolic arrhythmia in the first four weeks of pregnancy.
Material and methods. Dynamic observation was carried out for four weeks in 36 pregnant women with symptomatic ventricular extrasystole (group 1) and 24 pregnant women with asymptomatic extrasystole (group 2). Patients are examined weekly in the absence of therapy. Research methods include ECG registration, cardiac ultrasound, 24-h ECG monitoring, determination of human chorionic gonadotropin, TSH, T4(f).
Results. It is found that an increase in a duration of pregnancy leads to an increase in the number of symptomatic extrasystoles (p < 0.05) and a decrease in the number of asymptomatic ones (p < 0.05). A correlation dependence (p < 0.05) of human chorionic gonadotropin with TSH was shown at the 1st, 2nd, 3rd and 4th weeks of pregnancy and human chorionic gonadotropin with extrasystole at the 4th week. A threshold value of human chorionic gonadotropin is revealed, indicating an increase in amount of extrasystole.
Conclusion. With increasing gestational age, the number of symptomatic extra systoles increases. Human chorionic gonadotropin plays an important role in arrhythmogenesis during gestation.
Supporting agencies: The authors declare that there is no external funding for the exploration and analysis work
About the Authors
O. P. Vinogradova
Penza Institute of Advanced Training
Russian Federation
Russian Federation
Olga P. Vinogradova - Dr. Sci. (Med.), Head of the Department.
Penza
R. F. Rakhmatullov
Penza State University
Russian Federation
Russian Federation
Cand. Sci. (Med.), Associate Professor of the Department.
Penza
F. K. Rakhmatullov
Penza State University
Russian Federation
Russian Federation
Ruslan F. Rakhmatullaev - Dr. Sci. (Med.), Professor of the Department.
Penza
Y. A. Kandrashkina
Penza State University
Russian Federation
Russian Federation
Fagim K. Rakhmatullov - Cand. Sci. (Med.), Associate Professor.
Penza
M. A. Ostanin
State Budgetary Healthcare Institution Penza City Maternity Hospital
Russian Federation
Russian Federation
Maxim A. Ostanin - obstetrician-gynecologist.
Penza
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Review
For citations:
Vinogradova O.P., Rakhmatullov R.F., Rakhmatullov F.K., Kandrashkina Y.A., Ostanin M.A. Features of the influence of human chorionic gonadotropin on the course of extrasystolic arrhythmia in pregnant women. Astrakhan medical journal. 2025;20(2):92-104. (In Russ.) https://doi.org/10.17021/1992-6499-2025-2-92-104
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