Diagnostics of endogenous intoxication in workers of a large gas processing plant with liver pathology

When a person works in conditions of harmful production, the influence of additional adverse environmental influences on his body is noted. Therefore, it is important to develop and implement methods for assessing the formation and progression of risk factors for the development of chronic diseases, as well as pathological conditions of the body and environmental conditions that negatively affect the work of employees. Objective: to study the signs of endogenous intoxication in workers with liver pathology in large gas processing plants associated with the extraction and processing of gas with an increased content of hydrogen sulfide. Materials and methods of research: the values of the hematological index of intoxication (based on the results of a general blood test) and average weight molecules were studied based on the use of hematological and biochemical research methods in this group of employees (the main group, 972 people) compared with similar indicators for people who do not work in production with exposure to harmful factors, but observed in the same medical and preventive institution (control group, 225 people). Results. The presence of significant (p < 0.001) signs of endogenous intoxication in workers of harmful industries was revealed, their significant deterioration depending on the length of service in harmful working conditions, the predominance of increased values of medium-weight molecules and hematological index of intoxication compared with the control group. Conclusion. The results obtained confirm the presence of an additional toxic load on the body of workers in harmful industries.

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