To the question of the assessment of the cervical biopty culturome in a patient with moderate cervical intraepithelial dysplasia
https://doi.org/10.29039/1992-6499-2023-2-104-109
Abstract
In recent years, the role of microcenosis in the occurrence and progression of the pathology of various organs, including cervical cancer, has been actively discussed.
Purpose: to study the cervical microflora in a patient with moderate cervical dysplasia.
Material and research methods. An extended microbiological study of cervical mucosal cultures and cervical biopsy was performed in a patient with moderate cervical dysplasia. Cervical biopsy microcenosis was studied using a MALDI-ToF mass spectrometer (Bruker). The biocenosis of the cervical canal was studied on the basis of the polymerase chain reaction method, the Digene HPV test system test and bacteriological examination.
Research results. In the biopsy specimen of the cervix, a microflora not typical for the cervical biotope was found. In particular, microorganisms were found in the tissue of the cervix, which can cause the development of pathology of the oral cavity (Streptococcus oralis, Streptococcus mitis, Streptococcus anginosus, Streptococcus sanguinis) or intestinal dysbiosis (Alloscardovia omnicolens). At the same time, these bacteria were not found in the mucous membrane of the cervical canal.
Conclusion. Further research is needed to understand the causes and consequences of biocenosis differences in the altered tissue of the cervix and cervical canal.
About the Authors
S. M. Checko
Municipal Clinical Hospital No. 2 named after N.A. Semashko
Russian Federation
Russian Federation
C.M. Chechko, obstetrician-gynecologist, Department of Operative Gynecology
Samara
A. V. Lyamin
Samara State Medical University
Russian Federation
Russian Federation
A.V. Lyamin, Dr. Sci. (Med.), Associate Professor, Head of the Microbiological Department of the CDL
Samara
A. V. Kazakova
Samara State Medical University
Russian Federation
Russian Federation
A.V. Kazakova, Dr. Sci. (Med.), Associate Professor, Head of the Department of Obstetrics and Gynecology, Institute of Pediatrics
Samara
N. V. Sapozhkova
Municipal Clinical Hospital No. 2 named after N.A. Semashko
Russian Federation
Russian Federation
N.V. Sapozhkova, Head of the Department of Operative Gynecology
Samara
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Review
For citations:
Checko S.M., Lyamin A.V., Kazakova A.V., Sapozhkova N.V. To the question of the assessment of the cervical biopty culturome in a patient with moderate cervical intraepithelial dysplasia. Astrakhan medical journal. 2023;18(2):104–109. (In Russ.) https://doi.org/10.29039/1992-6499-2023-2-104-109
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