Prophylaxis of anastomositis after stomach resection
https://doi.org/10.29039/1992-6499-2023-2-24-30
Abstract
The clinical, immunological and endoscopic features of anastomositis were studied in patients after the stomach resection according to Billroth II in various modifications because of peptic ulcer disease. The study revealed the relationship in development of anastomositis with the level of populations T-lymphocytes, immunoregulatory index, circulating immune complexes, R-proteins in the early postoperative period as well as before the operation. Disturbances in the immune system may lead to decrease in stability of mucosa and to the increase of aggressive factors. The severity of disturbances in the functioning of the immune system is interrelated with the presence of Helicobacter pylori infection. The higher the antibody titers to the antigen CagA Helicobacter pylori, the more severe there may be the manifestations of immunopathological reactions and the more severe the clinical signs of anastomositis. Immunological indicators and their dynamics may be used both for the early diagnosis of anastomositis, and for the prognosis and prophylaxis of this postoperative complication.
About the Authors
S. V. Antonyan
Astrakhan State Medical University
Russian Federation
Russian Federation
S.V. Antonyan, Cand. Sci. (Med.), Associate Professor, Associate Professor of Department
Astrakhan
Y. V. Kuchin
Astrakhan State Medical University
Russian Federation
Russian Federation
Y.V. Kuchin, Dr. Sci. (Med.), Professor, Head of the Department
Astrakhan
T. N. Kudba
Astrakhan State Medical University
Russian Federation
Russian Federation
T.N. Kudba, Cand. Sci. (Med.), Assistant of the Department
Astrakhan
A. V. Zurnadghyants
Astrakhan State Medical University
Russian Federation
Russian Federation
A.V. Zurnadghyants, Cand. Sci. (Med.), Associate Professor, Associate Professor of Department
Astrakhan
R. D. Mustafin
Astrakhan State Medical University
Russian Federation
Russian Federation
R.D. Mustafin, Dr. Sci. (Med.), Professor, Head of Department
Astrakhan
V. V. Antonyan
Astrakhan State Medical University
Russian Federation
Russian Federation
V.V. Antonyan, Dr. Sci. (Med.), Associate Professor, Head of Department
Astrakhan
References
1. Zemlyanoy V. P., Sigua B. V., Danilov A. M., Kotkov P. A. Historical milestones in the development of pep-tic ulcer surgery (To the 135th anniversary of the successful gastric resection proposed by T. Bilroth). Vestnik khirurgii imeni I. I. Grekova = Grekov ҆s Bulletin of Surgery. 2016; 175 (6): 91–94. (In Russ.).
2. Vlasov A. P. Improvement of gastric resection surgery in non-standard conditions. Khirurgia. Zhurnal imeni N. I. Pirogova = Pirogov Journal of Surgery. 2020; (9): 20–27. (In Russ.).
3. Chernousov A., Khorobrykh T., Zubareva M., Vychuzhanin D., Gorbunov A., Abdulkhakimov N., Uddin L., Khorobrikh V., Gelmutdinova E. Surgical treatment for postgastrectomy syndromes: actual problems. Vrach = Doctor. 2019; 30 (6): 3–9. (In Russ.).
4. Fyodorov I. V. Late complications of gastric surgery. Moskovskiy khirurgicheskiy zhurnal = Moscow Surgi-cal Journal. 2015; (3): 27-32. (In Russ.).
5. Bogomolov N. I., Duchenko B. F., Tomskikh N. N. Postgastroresection syndromes. Vestnik khirurgicheskoy gastroenterologii = Herald of Surgical Gastroenterology. 2006; (1): 30–31. (In Russ.).
6. Tret'yakov A. A., Dronova O. B. Gastroesophageal reflux disease in patients after resection of the stomach. Vestnik khirurgii = Gazetter surgery. 2008; (6): 26–29. (In Russ.).
7. Zherlov G. K., Rudaya N. S., Koshel' A. P., Sokolov S. A., Lobachev R. S., Sin'ko S. P. Modern technology in the diagnosis of complicated anastomositis. Annaly khirurgii = Annals of surgery. 2004; (4): 33–37. (In Russ.).
8. Mishanina L. S., Matveeva L. V., Mosina L. M. Level of circulating immune complexes with ulcers. Ros-siyskiy zhurnal gastroenterologii, gepatologii, koloproktologii = Russian Journal of gastroenterology, hepatology, colo-proctology. 2013; 23 (5): 24. (In Russ.).
9. Golubkina E. V., Levitan B. N., Umerova A. R., Kamneva N. V. The effectiveness of standard triple anti-Helicobacter I line therapy is the experience of the last decade. Terapiya = Therapy. 2019; 5 (4): 94-102. (In Russ.).
10. Narayanan M., Reddy K. M., Marsicana E. Peptic Ulcer Disease and Helicobacter pylori infection. Science of medicine/Feature series. Missouri Medicine. 2018; 115 (3): 219–224.
11. Fashner J., Gitu A. C. Diagnosis and Treatment of Peptic Ulcer Disease and H. pylori Infection. American Family Physician. 2015; 91 (4): 236–242.
12. Smolkina A. V., Midlenko V. I., Zajcev A. V., Zajceva O. B. Optimization of complex treatment of early postgastrectomy complications in patients with gastric ulcer and duodenal ulcer using neuroaxial methods. Med-itsinskiy almanakh = Medical almanac. 2011; 2 (15): 94-96. (In Russ.).
13. Nesterova I. V. Immunopathogenesis and immunotherapy ulcers. Vestnik khirurgicheskoy gastroenterologii = Gazetter Surgical Gastroenterology. 2006; (1): 116. (In Russ.).
14. Romenskaya V. A. Immunomodulating therapy cytokines in complex treatment ulcers. Vestnik khirur-gicheskoy gastroenterologii = Herald of Surgical Gastroenterology. 2006; (1): 129. (In Russ.).
15. Zemskov A. M. Clinical immunology. Moscow: GEOTAR-Media; 2008. 432 p. (In Russ.).
16. Kishkun A. A. Guide to laboratory diagnostic Methods. Moscow : GEOTAR-Media; 2009. 800 p. (In Russ.).
Review
For citations:
Antonyan S.V., Kuchin Y.V., Kudba T.N., Zurnadghyants A.V., Mustafin R.D., Antonyan V.V. Prophylaxis of anastomositis after stomach resection. Astrakhan medical journal. 2023;18(2):24-30. (In Russ.) https://doi.org/10.29039/1992-6499-2023-2-24-30
Views:
1051
Email this article 