Preview

Astrakhan medical journal

Advanced search

Pathology of the urinary system and its frequency in children with COVID-19

https://doi.org/10.29039/1992-6499-2023-1-39-49

Abstract

   This review presents data on endothelial dysfunction and the mechanisms of its development in coronavirus disease. The possible pathology of the urinary system and its frequency in children against the background of COVID-19, which is mainly due to endothelial dysfunction, is described. Displayed studies on the frequency of urinary tract infections in children and adolescents during a pandemic, which depended on the level of quarantine measures, which in turn affect the neuro-psychological causes of bladder dysfunction, limited timely access to medical care, etc. A systematic review of studies published in English from 2000 to 2019 was performed (with predominant inclusion (84,6 %) of data for the last 2 years) using PubMed, ScienceDirect, ProQuest, GoogleScholar, Cochrane, Medline, AMED databases., EMBASE, CINHAL, SportDiscus, Scopus and PEDro. The review included review articles, meta-analyses, qualitative studies, retrospective and prospective studies.

About the Authors

D. V. Yarovaya
Astrakhan State Medical University
Russian Federation

Darya V. Yarovaya, postgraduate student

Astrakhan



O. A. Bashkina
Astrakhan State Medical University
Russian Federation

Olga A. Bashkina, Dr. Sci. (Med.), Professor, Head of Department

Astrakhan



E. V. Krasilova
Regional Children's Clinical Hospital named after N. N. Silishcheva
Russian Federation

Elena V. Krasilova, Cand. Sci. (Med.), Head of the Department

Astrakhan



M. A. Samotrueva
Astrakhan State Medical University
Russian Federation

Marina A. Samotrueva, Dr. Sci. (Med.), Professor, Head of Department

Astrakhan



E. B. Kasymova
Astrakhan State Medical University
Russian Federation

Ekaterina B. Kasymova, Cand. Sci. (Med.), Associate Professor

Astrakhan



References

1. Kabanova A., Gavriilaki, E., Pelzer, B. W., Brunetti L., Maiques-Diaz A. Effect of the COVID-19 pandemic on laboratory and clinical research: a testimony and a call to action from researchers // Hemasphere. 2020. Vol. 4. no. 6. P. e499. doi: 10.1097/HS9.0000000000000499.

2. Phillips S., Williams M. A. Confronting our next national health disaster - long-haul covid. The New England Journal of Medicine. 2021. Vol. 385. P. 577–579. doi: 10.1056/NEJMp2109285.

3. Gavriilaki E., Eftychidis I., Papassotiriou I. Update on endothelial dysfunction in COVID-19: severe disease, long COVID-19 and pediatric characteristics // Journal of Laboratory Medicine. 2021. Vol. 45, no. 6. P. 293–302. doi: 10.1515/labmed-2021-0134.

4. Feldstein L. R., Rose, E. B., Horwitz S. M., Collins J. P., Newhams M. M., Son M. B. F., Newburger J. W., Kleinman L. C., Heidemann S. M., Martin A. A., Singh A. R., Li S., Tarquinio K. M., Jaggi P., Oster M. E., Zackai S. P., Gillen J., Ratner A. J., Walsh R. F., Fitzgerald J. C., Keenaghan M. A., Alharash H., Doymaz S., Clouser K. N., Giuliano J. S. Jr, Gupta A., Parker R. M., Maddux A. B., Havalad V., Ramsingh S., Bukulmez H., Bradford T. T., Smith L. S., Tenforde M. W., Carroll C. L., Riggs B. J., Gertz S. J., Daube A., Lansell A., Coronado Munoz A., Hobbs C. V., Marohn K. L., Halasa N. B., Patel M. M., Randolph A. G. Multisystem inflammatory syndrome in U. S. children and adolescents. // The New England Journal of Medicine 2020. Vol. 383, no. 4. P. 334–346. doi: 10.1056/NEJMoa2021680.

5. Riphagen S., Gomez X., Gonzalez-Martinez C., Wilkinson N., Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic // Lancet. 2020. Vol. 395, no. 10237. P. 1607–1608. doi: 10.1016/S0140-6736(20)31094-1.

6. Whittaker E., Bamford A., Kenny J., Kaforou M., Jones C. E., Shah P., Ramnarayan P., Fraisse A., Miller O., Davies P., Kucera F., Brierley J., McDougall M., Carter M., Tremoulet A., Shimizu C., Herberg J., Burns J. C., Lyall H., Levin M. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 // The Journal of the American Medical Association. 2020. Vol. 324, no. 3. P. 259–269. doi: 10.1001/jama.2020.10369.

7. Tetro J. A. Is COVID-19 receiving ADE from other coronaviruses? // Microb. Infect. 2020. Vol. 22, no. 2. P. 72–73. doi: 10.1016/j.micinf.2020.02.006.

8. Rajendran P., Rengarajan T., Thangavel J., Nishigaki Y., Sakthisekaran D., Sethi G., Nishigaki I. The vascular endothelium and human diseases // International Journal of Biological Sciences. 2013. Vol. 9, no. 10. P. 1057–1069. doi: 10.7150/ijbs.7502.

9. Godo S., Shimokawa H. Endothelial functions // Arterioscler Thromb. Vasc. Biol. 2017. Vol. 37, no. 9. P. e108–e114. doi: 10.1161/ATVBAHA.117.309813.

10. Gkaliagkousi E., Gavriilaki E., Triantafyllou A., Douma S. Clinical significance of endothelial dysfunction in essential hypertension. Curr. Hypertens. Rep. 2015. Vol. 17. P. 85. doi: 10.1007/s11906-015-0596-3.

11. Nägele M. P., Haubner B., Tanner F. C., Ruschitzka F., Flammer A. J. Endothelial dysfunction in COVID-19: Current findings and therapeutic implications // Atherosclerosis. 2020. Vol. 314. P. 58–62. doi: 10.1016/j.atherosclerosis.2020.10.014.

12. Wan Y., Shang J., Graham R., Baric R. S., Li F. Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus // Journal of Virology. 2020. Vol. 94, no. 7. P. e00127-20. doi: 10.1128/JVI.00127-20.

13. Zou X., Chen K., Zou J., Han P., Hao J., Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection // Front Med. 2020. Vol. 14, no. 2. P. 185–192. doi: 10.1007/s11684-020-0754-0.

14. Wu H. H. L., Shenoy M., Kalra P. A., Chinnadurai R. Intrinsic Kidney Pathology Following COVID-19 Infection in Children and Adolescents: A Systematic Review // Children. 2022. Vol. 9, no. 1. P. 1–14. doi: 10.3390/children9010003.

15. Su H., Yang M., Wan C., Yi L. X., Tang F., Zhu H. Y., Yi F., Yang H. C., Fogo A. B., Nie X., Zhang C. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China // Kidney Int. 2020. Vol. 98, no. 1. P. 219–227. doi: 10.1016/j.kint.2020.04.003.

16. Larsen C. P., Bourne T. D., Wilson J. D., Saqqa O., Sharshir M. D. Collapsing glomerulopathy in a patient with COVID-19 // Kidney Int. Rep. 2020. Vol. 5, no. 6. P. 935–939. doi: 10.1016/j.ekir.2020.04.002.

17. Ye Q., Wang B., Mao J. The pathogenesis and treatment of the ‘cytokine storm’ in COVID-19 // The Journal of Infectious Diseases. 2020. Vol. 80. no. 6. P. 607–613. doi: 10.1016/j.jinf.2020.03.037.

18. Ossina N. K., Cannas A., Powers V. C., Fitzpatrick P., Knight J. D., Gilbert James R., Shekhtman E., Tomei L. D., Umansky S., Kiefer M. C. Interferon-gamma modulates a p53-independent apoptotic pathway and apoptosis-related gene expression // Journal of Biological Chemistry. 1997. Vol. 272. P. 16351–16357. doi: 10.1074/jbc.272.26.16351.

19. Wu H., Larsen C. P., Hernandez-Arroyo C. F., Mohamed M. M. B., Caza T., Sharshir M., Chughtai A., Xie L., Gimenez J. M., Sandow T. A., Lusco M. A., Yang H., Acheampong E., Rosales I. A., Colvin R. B., Fogo A. B., Velez J. C. Q. AKI and Collapsing Glomerulopathy Associated with COVID-19 and APOL 1 High-Risk Genotype // Journal of the American Society of Nephrology. 2020. Vol. 31, no. 8. P. 1688–1695. doi: 10.1681/ASN.2020050558.

20. Iba T., Connors J. M., Levy J. H. The coagulopathy, endotheliopathy, and vasculitis of COVID-19 // Inflamm. Res. 2020. Vol. 69. P. 1181–1189. doi: 10.1007/s00011-020-01401-6.

21. Suso A. S., Mon C., Oñate Alonso I., Galindo Romo, K., Juarez R. C., Ramírez C. L., Sánchez Sánchez M., Mercado Valdivia V., Ortiz Librero M., Oliet Pala A., Ortega Marcos O., Herrero Berron J. C., Silvestre Torner N., Alonso Riaño M, Pascual Martin A. IgA Vasculitis with Nephritis (Henoch-Schönlein Purpura) in a COVID-19 Patient // Kidney Int. Rep. 2020. Vol. 5, no. 11. P. 2074–2078. doi: 10.1016/j.ekir.2020.08.016.

22. Alabbas A., Kirpalani A., Morgan C., Mammen C., Licht C., Phan V., Wade A., Harvey E., Zappitelli M., Clark E. G., Hiremath S., Soroka S. D., Wald R., Weir M. A., Chanchlani R., Lemaire M. Canadian Association of Paediatric Nephrologists COVID-19 Rapid Response: Guidelines for Management of Acute Kidney Injury in Children // Canadian Journal of Kidney Health and Disease. 2021. Vol. 8. P. 1–17. doi: 10.1177/2054358121990135.

23. Lu X., Zhang L., Du H., Zhang J., Li Y. Y., Qu J., Zhang W., Wang Y., Bao S., Li Y., Wu C., Liu H., Liu D., Shao J., Peng X., Yang Y., Liu Z., Xiang Y., Zhang F., Silva R. M., Pinkerton K. E., Shen K., Xiao H., Xu S., Wong G. W. K. SARS-CoV-2 infection in children // The New England Journal of Medicine. 2020. Vol. 382. P. 1663–1665. doi: 10.1056/NEJMc2005073.

24. Xu Y., Li X., Zhu B., Liang H., Fang C., Gong Y., Guo Q., Sun X., Zhao D., Shen J., Zhang H., Liu H., Xia H., Tang J., Zhang K., Gong S. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. // Nat. Med. 2020. Vol. 26, no. 4. P. 502–505. doi: 10.1038/s41591-020-0817-4.

25. Bjornstad E. C., Krallman K. A., Askenazi D., Zappitelli M., Goldstein S. L., Basu R. K. Preliminary Assessment of Acute Kidney Injury in Critically Ill Children Associated with SARS-CoV-2 Infection: A Multicenter Cross-Sectional Analysis // Clinical Journal of the American Society of Nephrology. 2021. Vol. 16, no. 3. P. 446–448. doi: 10.2215/CJN.11470720.

26. Raina R., Mawby I., Chakraborty R., Sethi S. K., Mathur K., Mahesh S., Forbes M. Acute kidney injury in COVID-19 pediatric patients in North America: Analysis of the virtual pediatric systems data // PLOS ONE. 2022. Vol. 17, no. 4. P. e0266737. doi: 10.1371/journal.pone.0266737.

27. Derespina K. R., Kaushik S., Plichta A., Conway E. E. Jr., Bercow A., Choi J., Eisenberg R., Gillen J., Sen A. I., Hennigan C. M., Zerihun L. M., Doymaz S., Keenaghan M. A., Jarrin S., Oulds F., Gupta M., Pierre L., Grageda M., Ushay H. M., Nadkarni V. M., Agus M. S. D., Medar S. S. Clinical manifestations and outcomes of critically ill children and adolescents with coronavirus disease 2019 in New York City // The Journal of Pediatrics. 2020. Vol. 226. P. 55–63. doi: 10.1016/j.jpeds.2020.07.039.

28. Grimaud M., Starck J., Levy M., Marais C., Chareyre J., Khraiche D., Leruez-Ville M., Quartier P., Léger P. L., Geslain G, Semaan N, Moulin F, Bendavid M, Jean S, Poncelet G, Renolleau S, Oualha M. Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children // Ann Intensive Care. 2020. Vol. 10. P. 6968. doi: 10.1186/s13613-020-00690-8.

29. Kari J. A., Shalaby M. A., Albanna A. S., Alahmadi T. S., Alherbish A., Alhasan K. A. Acute kidney injury in children with COVID-19: a retrospective study // BMC Nephrol. 2021. Vol. 22, no. 1. P. 202. doi: 10.1186/s12882-021-02389-9.

30. Mamishi S., Movahedi Z., Mohammadi M., Ziaee V., Khodabandeh M., Abdolsalehi M. R., Navaeian A., Heydari H., Mahmoudi S., Pourakbari B. Multisystem inflammatory syndrome associated with SARS-CoV-2 infection in 45 children: a first report from Iran // Epidemiol Infect. 2020. Vol. 148. P. e196. doi: 10.1017/S095026882000196X.

31. Stewart D. J., Hartley J. C., Johnson M., Marks S. D., du Pré P., Stojanovic J. Renal dysfunction in hospitalised children with COVID-19 // Lancet Child Adolesc. Health. 2020. Vol. 4, no. 8. P. e28–e29. doi: 10.1016/S2352-4642(20)30178-4.

32. Livingston E., Bucher K. Coronavirus Disease 2019 (COVID-19) in Italy // JAMA. 2020. Vol. 323, no. 14. P. 1335. doi: 10.1001/jama.2020.4344.

33. Tagarro A., Epalza C., Santos M., Sanz-Santaeufemia F. J., Otheo E., Moraleda C., Calvo C. Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in Madrid, Spain // JAMA Pediatr. 2020. Vol. 174, no. 10. P. 1009. doi: 10.1001/jamapediatrics.2020.1346.

34. Krishnasamy S., Mantan M., Mishra K., Kapoor K., Brijwal M., Kumar M., Sharma S., Swarnim S., Gaind R., Khandelwal P., Hari P., Sinha A., Bagga A. SARS-CoV-2 infection in children with chronic kidney disease // Pediatr. Nephrol. 2022. Vol. 37, no. 4. P. 849–857. doi: 10.1007/s00467-021-05218-1.

35. Marlais M., Wlodkowski T., Al-Akash S., Ananin P., Bandi V. K., Baudouin V., Boyer O., Vásquez L., Govindan S., Hooman N., Ijaz I., Loza R., Melgosa M., Pande N., Pape L., Saha A., Samsonov D., Schreuder M. F., Sharma J., Siddiqui S., Sinha R., Stewart H., Tasic V., Tönshoff B., Twombley K., Upadhyay K., Vivarelli M., Weaver D. J., Woroniecki R., Schaefer F., Tullus K. COVID-19 in children treated with immunosuppressive medication for kidney diseases // Arch. Dis. Child. 2020. Vol. 106, no. 8. P.798–801. doi: 10.1136/archdischild-2020-320616.

36. Blumfield E., Levin T. L., Kurian J., Lee E. Y., Liszewski M. C. Imaging findings in multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) // American Journal of Roentgenology. 2021. Vol. 216, no. 2. P. 507–517. doi: 10.2214/AJR.20.24032.

37. Berteloot L., Berthaud R., Temmam S., Lozach C., Zanelli E., Blanc T., Heloury Y., Capito C., Chardot C., Sarnacki S., Garcelon N., Lacaille F., Charbit M., Pastural M., Rabant M., Boddaert N., Leruez-Ville M., Eloit M, Sermet-Gaudelus I., Dehoux L., Boyer O. Arterial abnormalities identified in kidneys transplanted into children during the COVID-19 pandemic // American Journal of Transplantation. 2020. Vol. 21, no. 5. P. 1937–1943. doi: 10.1111/ajt.16464.

38. Golberstein E., Wen H., Miller B. F. Coronavirus disease 2019 (COVID-19) and mental health for children and adolescents // JAMA Pediatr. 2020. Vol. 174, no. 9. P. 819–820. doi: 10.1001/jamapediatrics.2020.1456.

39. Harper L., Bagli D., Kaefer M., Kalfa N., Beckers G. M. A., Nieuwhof-Leppink A. J., Fossum M., Herbst K. W. COVID-19 and research in pediatric urology // Journal of Pediatric Urology. 2021. Vol. 17, no. 4. P. 569–570. doi: 10.1016/j.jpurol.2021.04.004.

40. Hatoun J., Correa E. T., Donahue S. M. A., Vernacchio L. Social distancing for COVID-19 and diagnoses of other infectious diseases in children // Pediatrics. 2020. Vol. 146, no. 4. P. e2020006460. doi: 10.1542/peds.2020-006460.

41. Liguoro I., Pilotto C., Vergine M., Pusiol A., Vidal E., Cogo P. The impact of COVID-19 on a tertiary care pediatric emergency department // European Journal of Pediatrics. 2021. Vol. 180. P. 1497–1504. doi: 10.1007/s00431-020-03909-9.

42. Flores-Mireles A., Walker J., Caparon M., Hultgren S. J. Urinary tract infections: epidemiology, mechanisms of infection and treatment options // Nat. Rev. Microbiol. 2015. Vol. 13. P. 269–284. doi: 10.1038/nrmicro3432.

43. Twaij M. Urinary tract infection in children: a review of its pathogenesis and risk factors // The Journal of the Royal Society for the Promotion of Health. 2000. Vol. 120, no. 4. P. 220–226. doi: 10.1177/146642400012000408.

44. Kuitunen I., Artama, M., Haapanen, M., Renko M. Urinary tract infections decreased in Finnish children during the COVID-19 pandemic // European Journal of Pediatrics. 2022. Vol. 181. P. 1979–1984. doi: 10.1007/s00431-022-04389-9.

45. Urinary tract infections (2019) Current care guidelines. Working group set by the Finnish Society of Infectious Diseases, Finnish Society of Clinical Chemistry, Finnish Paediatric Society, Finnish Urology Association and The Finnish Association of General Practitioners. Helsinki: The Finnish Medical Society Duodecim. Accessed 10 Jun 2021. URL: www.kaypahoito.fi (In Finnish).

46. Sterky E., Olsson-Åkefeldt S., Hertting O., Herlenius E., Alfven T., Ryd Rinder M., Rhedin S., Hildenwall H. Persistent symptoms in Swedish children after hospitalisation due to COVID-19 // Acta Paediatr. 2021. Vol. 110, no. 9. P. 2578–2580. doi: 10.1111/apa.15999.


Review

For citations:


Yarovaya D.V., Bashkina O.A., Krasilova E.V., Samotrueva M.A., Kasymova E.B. Pathology of the urinary system and its frequency in children with COVID-19. Astrakhan medical journal. 2023;18(1):39-49. (In Russ.) https://doi.org/10.29039/1992-6499-2023-1-39-49

Views: 494


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1992-6499 (Print)