RELATIONSHIP BETWEEN TOBACCO SMOKING DURATION AND KLOTHO PROTEIN LEVEL IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

The aim of the research: to study and analyze the level of Klotho protein in patients with chronic obstructive pulmonary disease depending on the tobacco smoking duration. Materials and Methods. Patients with chronic obstructive pulmonary disease (n = 54) with moderate and severe stages of the disease were divided into three subgroups of patients depending of the tobacco smoking duration: the first subgroup - from 10 to 20 years, the second subgroup - from 20 to 30 years, and the third subgroup - from 30 and more years of tobacco smoking duration. Somatically healthy volunteers (n = 30) were examined as a control group. Results. The Klotho protein level in patients with chronic obstructive pulmonary disease was statistically significantly lower (p < 0,001) than in somatically healthy volunteers. The value of the Klotho protein level also had statistically significant differences in the analyzed subgroups of patients with chronic obstructive pulmonary disease (depending on the tobacco smoking duration). According to the results of the correlation analysis, a relationship was revealed between the level of Klotho protein and the smoking index, and also between the level of Klotho protein and the tobacco smoking duration. Conclusions. The lowest level of Klotho protein was in the subgroup of patients with tobacco smoking duration of 30 and more years. At the same time, the Klotho protein level in subgroup of patients with tobacco smoking duration from 30 and more years was statistically significantly lower compared to the subgroups of patients with less tobacco smoking duration (from 20 to 30 years and from 10 to 20 years). A large relationship between the level of Klotho protein and tobacco smoking duration was registered in the subgroup of patients with tobacco smoking duration of 30 and more years.

Klotho protein, chronic obstructive pulmonary disease, myocardial infarction, tobacco smoking duration

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