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STIMULATING ROLE OF STAPHYLOCOCCUS AUREUS SplA-PROTEINASE IN THE DEVELOPMENT OF ALLERGIC TYPE OF IMMUNE REACTIONS IN BACTERIOUS CARRIERS WITH ALLERGIC RHINITIS
https://doi.org/10.17021/2020.15.4.89.97
Abstract
Among the allergens involved in the development of allergic rhinitis, glycoproteins are found that are contained not only in the particles of inhaled air, but also in the vital products of the nasal microbiota, which colonizes the nasal mucosa in patients with allergic rhinitis. Among proteolytic enzymes, secreted bacterial serine Spl proteinase of Staphylococcus aureus are of significant interest. The study aimed to study the potentiation of the Th2 profile of the immune response to Spl serine proteinase of Staphylococcus aureus, as an important representative of the microbiota of the mucous membranes of the upper respiratory tract in patients with allergic rhinitis. Results and discussion. The spl operon genes are transcribed at a 5,5 kb genome site. It has been established that in patients with allergic rhinitis, Staphylococcus aureus isolates containing from 2 to 4 spl-operon genes, as well as isolates containing one spl-operon (splA) gene, dominate. It was shown that the resulting recombinant Staphylococcus aureus SplA proteinase can induce high levels of Th2-type cytokines in patients with allergic rhinitis. Staphylococcus aureus secretoma Spl-proteinases, identified by mass spectrometry, can bind to serum reactins (IgE antibodies) in patients with allergic rhinitis.
About the Authors
Y. A. Tyurin
Kazan Scientific Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
G. Sh. Isaeva
Kazan Scientific Research Institute of Epidemiology and Microbiology; Kazan State Medical University
Russian Federation
Russian Federation
R. Z. Khayrullin
Kazan Scientific Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
A. A. Sharifullina
Specialized clinic for infectious and allergic diseases,Kazan Scientific Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
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Review
For citations:
Tyurin Y.A., Isaeva G.Sh., Khayrullin R.Z., Sharifullina A.A. STIMULATING ROLE OF STAPHYLOCOCCUS AUREUS SplA-PROTEINASE IN THE DEVELOPMENT OF ALLERGIC TYPE OF IMMUNE REACTIONS IN BACTERIOUS CARRIERS WITH ALLERGIC RHINITIS. Astrakhan medical journal. 2020;15(4):89-97. (In Russ.) https://doi.org/10.17021/2020.15.4.89.97
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