АССОЦИАЦИЯ ГЕНОТИПА ФЕРМЕНТА БИОТРАНСФОРМАЦИИ КСЕНОБИОТИКА (GSTM1) У БОЛЬНЫХ ТУБЕРКУЛЕЗОМ ЛЕГКИХ С ЭФФЕКТИВНОСТЬЮ ПРОВЕДЕНИЯ ИНТЕНСИВНОЙ ФАЗЫ ХИМИОТЕРАПИИ

Аннотация. В исследование было включено 335 больных туберкулезом легких в возрасте от 18 до 65 лет, получающих интенсивную фазу химиотерапии, среди которых было 212 больных с впервые выявленным туберкулезом легких и 123 – с хроническим.

Ассоциации аллелей и генотипов с предрасположенностью к туберкулезу легких оценивали с помощью отношения шансов (OR).

В ходе проведенного исследования выявлено, что у больных с впервые выявленным туберкулезом легких рубцевание полостей распада в 2,9 раза чаще ассоциируется с генотипом ЕЕ гена GSTM1, в то время как у больных с хроническим туберкулезом легких -  в 2,4 раза чаще, по сравнению с генотипом DD гена GSTM1 (р<0,001).

Уменьшение инфильтрации легочной ткани в 5,3 раза чаще ассоциировано с генотипом ЕЕ гена GSTM1 у больных с впервые выявленным туберкулезом легких, в то время как у больных с хроническим туберкулезом легких – в 1,7 раза, по сравнению с генотипом DD гена GSTM1 (р<0,001).

Summary. The research included 335 TB patients of lungs aged from 18 up to 65 years receiving an intensive phase of chemotherapy among which there were 212 patients with for the first time the detected pulmonary tuberculosis and 123 – with chronic.

Associations of alleles and genotypes with predisposition to a pulmonary tuberculosis estimated by means of the relation of chances (OR).

During the conducted research it is revealed that at patients with for the first time the detected pulmonary tuberculosis scarring of cavities of disintegration 2.9 times more often is associated with a genotype of ITS gene of GSTM1 while at patients with a chronic pulmonary tuberculosis - is 2.4 times more often, in comparison with a genotype of the DD gene of GSTM1 (r <0.001).

Reduction of infiltration of pulmonary fabric 5.3 times more often is associated with a genotype of ITS gene of GSTM1 at patients with for the first time the detected pulmonary tuberculosis while at patients with a chronic pulmonary tuberculosis – by 1.7 times, in comparison with a genotype of the DD gene of GSTM1 (r <0.001).

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