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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">astmed</journal-id><journal-title-group><journal-title xml:lang="ru">Астраханский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Astrakhan medical journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1992-6499</issn><publisher><publisher-name>ФГБОУ ВО Астраханский ГМУ Минздрава России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17021/1992-6499-2026-2-127-134</article-id><article-id custom-type="elpub" pub-id-type="custom">astmed-743</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Особенности клинического течения желчнокаменной болезни у детей разных возрастных групп</article-title><trans-title-group xml:lang="en"><trans-title>Clinical features of gallstone disease in children of different age groups</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1083-2807</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Первишко</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pervishko</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Первишко Олеся Валерьевна - кандидат медицинских наук, доцент, заведующий кафедрой педиатрии № 1.</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Olesya V. Pervishko - Cand. Sci. (Med.), Associate Professor, Head of the Department, Kuban State Medical University.</p><p>Krasnodar</p></bio><email xlink:type="simple">ole-pevishko@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0606-5836</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иваненко</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanenko</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иваненко Алина Станиславовна - ассистент кафедры педиатрии № 1.</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Alina S. Ivanenko - Assistant of the Department, Kuban State Medical University.</p><p>Krasnodar</p></bio><email xlink:type="simple">doctor_alj@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2175-1239</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маталаева</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Matalaeva</surname><given-names>S. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маталаева Светлана Юрьевна - кандидат медицинских наук, доцент кафедры педиатрии № 1.</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Svetlana Y. Matalaeva - Cand. Sci. (Med.), Associate Professor of the Department, Kuban State Medical University.</p><p>Krasnodar</p></bio><email xlink:type="simple">luludi@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-5699-8158</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Молоховская</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Molokhovskaya</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Молоховская Василиса Владимировна - студент педиатрического факультета.</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Vasilisa V. Molokhovskaya - student, Kuban State Medical University.</p><p>Krasnodar</p></bio><email xlink:type="simple">molokhovskya@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кубанский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>05</day><month>08</month><year>2026</year></pub-date><volume>21</volume><issue>2</issue><fpage>127</fpage><lpage>134</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Первишко О.В., Иваненко А.С., Маталаева С.Ю., Молоховская В.В., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Первишко О.В., Иваненко А.С., Маталаева С.Ю., Молоховская В.В.</copyright-holder><copyright-holder xml:lang="en">Pervishko O.V., Ivanenko A.S., Matalaeva S.U., Molokhovskaya V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.astmedj.ru/jour/article/view/743">https://www.astmedj.ru/jour/article/view/743</self-uri><abstract><p>Ранняя диагностика желчнокаменной болезни в детском возрасте представляет определенные трудности в практике врача-педиатра. Цель исследования. Выявление особенностей клинического течения желчнокаменной болезни у детей в различных возрастных группах. Материалы и методы. Исследование проводилось при участии 71 ребенка с подтвержденным диагнозом желчнокаменной болезни в возрасте от 0 до 18 лет. Пациенты были разделены на группы в зависимости от клинического течения желчнокаменной болезни: бессимптомную форму имели 38 детей, диспепсическую – 20 пациентов, болевую – 13. Всем пациентам проводился перечень лабораторно-инструментальных исследований. Результаты исследования. Достоверно установлена прямая связь между половозрастными особенностями пациента и клиническим течением желчнокаменной болезни. Диспепсическая форма выявлялась у обоих полов в младших возрастных группах и часто сопровождалась реактивными изменениями поджелудочной железы и инфицированием Helicobacter pylori. Болевая форма чаще регистрировалась у девочек подросткового возраста и характеризовалась выраженными изменениями слизистой пищевода, включая эрозивный эзофагит. Бессимптомная форма желчнокаменной болезни была характерна для подростков мужского пола и ассоциировалась с аномалиями формы желчного пузыря. Заключение. Полученные данные подчёркивают значение половозрастного подхода при оценке клинического течения желчнокаменной болезни у детей и подтверждают необходимость индивидуализации наблюдения и диагностики.</p></abstract><trans-abstract xml:lang="en"><p>Early diagnosis of gallstones in children presents certain challenges for pediatricians. The purpose of the study. Identification of the clinical features of gallstone disease in children of different ages. Materials and methods. The study involved 71 children diagnosed with gallstone disease conditions between the ages of 0 and 18. The participants were divided into three groups based on their clinical presentation: 38 had an asymptomatic form, 20 had dyspeptic symptoms, and 13 had pain. All participants underwent a series of lab and imaging tests. Tre results of the study. A reliable relationship was found between sex and age and the clinical presentation of gallstone disease. Dyspeptic symptoms were found in both sexes in younger children and were often accompanied by pancreatic abnormalities and Helicobacter pylori infection. Painful symptoms were more common in adolescent girls and were characterized by significant changes in the esophagus, including erosive esophagitis. The asymptomatic form of gallstone disease is common in male adolescents and is associated with irregularities in the shape of the gallbladder. Conclusion. The findings emphasize the significance of considering gender and age when assessing the clinical course of gallstone disease in children, and they confirm the necessity for personalized monitoring and diagnosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>желчнокаменная болезнь</kwd><kwd>дети</kwd><kwd>клинические формы</kwd><kwd>эндоскопия</kwd><kwd>ультразвуковое исследование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gallstone disease</kwd><kwd>children</kwd><kwd>clinical forms</kwd><kwd>endoscopy</kwd><kwd>ultrasound</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wong M. C. Y., Incerti F., Avanzini S., Palo F., Sertorio F., Damasio M. B., Arrigo S., Gandullia P., Mattioli G. Cholelithiasis management in a third-level pediatric center: case series and literature review // Updates in Surgery. 2022. Vol. 74. 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