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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">astmed</journal-id><journal-title-group><journal-title xml:lang="ru">Астраханский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Astrakhan medical journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1992-6499</issn><publisher><publisher-name>ФГБОУ ВО Астраханский ГМУ Минздрава России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17021/1992-6499-2026-2-135-147</article-id><article-id custom-type="elpub" pub-id-type="custom">astmed-740</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Значение показателей общего анализа крови у кардиохирургических пациентов с COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>The importance of general blood test indicators in cardiac surgery patients with COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3544-2266</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петрова Ольга Владимировна - доктор медицинских наук, доцент, заведующий клинико-диагностической лаборатории.</p><p>Астрахань</p></bio><bio xml:lang="en"><p>Olga V. Petrova - Dr. Sci. (Med.), Professor, Head of the Laboratory, Federal Center of Cardiovascular Surgery.</p><p>Astrakhan</p></bio><email xlink:type="simple">students_asma@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-8700-0065</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джалалова</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhalalova</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джалалова Ирина Георгиевна - врач клинической лабораторной диагностики.</p><p>Астрахань</p></bio><bio xml:lang="en"><p>Irina G. Dzhalalova - physician clinical laboratory diagnostics, Federal Center of Cardiovascular Surgery.</p><p>Astrakhan</p></bio><email xlink:type="simple">irinadj-777@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6754-6348</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Твердохлебова</surname><given-names>Д. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Tverdokhlebova</surname><given-names>D. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Твердохлебова Диана Камильевна - врач клинической лабораторной диагностики.</p><p>Астрахань</p></bio><bio xml:lang="en"><p>Diana K. Tverdokhlebova - physician clinical laboratory diagnostics, Federal Center of Cardiovascular Surgery.</p><p>Astrakhan</p></bio><email xlink:type="simple">tverdiana@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-7680-9769</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бирюкова</surname><given-names>Л. A.</given-names></name><name name-style="western" xml:lang="en"><surname>Biryukova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бирюкова Любовь Алексеевна - кандидат медицинских наук, врач кардиолог.</p><p>Астрахань</p></bio><bio xml:lang="en"><p>Lyubov A. Biryukova - Cand. Sci. (Med.), cardiologist, Federal Center of Cardiovascular Surgery.</p><p>Astrakhan</p></bio><email xlink:type="simple">birukoval@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1296-2031</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шашин</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shashin</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шашин Сергей Александрович - доктор медицинских наук, доцент, профессор кафедры хирургических болезней стоматологического факультета.</p><p>Астрахань</p></bio><bio xml:lang="en"><p>Sergey A. Shashin - Dr. Sci. (Med.), Professor, Professor of the Department, Astrakhan State Medical University.</p><p>Astrakhan</p></bio><email xlink:type="simple">shashin_sergey@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-0637-1427</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колесников</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolesnikov</surname><given-names>V. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Колесников Владимир Николаевич - кандидат медицинских наук, главный врач.</p><p>Астрахань</p></bio><bio xml:lang="en"><p>Vladimir N. Kolesnikov - Cand. Sci. (Med.), Chief Physician, Federal Center of Cardiovascular Surgery.</p><p>Astrakhan</p></bio><email xlink:type="simple">KolesnikovVN@astra-cardio.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральный центр сердечно-сосудистой хирургии</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Center of Cardiovascular Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Астраханский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Astrakhan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>05</day><month>08</month><year>2026</year></pub-date><volume>21</volume><issue>2</issue><fpage>135</fpage><lpage>147</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Петрова О.В., Джалалова И.Г., Твердохлебова Д.К., Бирюкова Л.A., Шашин С.А., Колесников В.Н., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Петрова О.В., Джалалова И.Г., Твердохлебова Д.К., Бирюкова Л.A., Шашин С.А., Колесников В.Н.</copyright-holder><copyright-holder xml:lang="en">Petrova O.V., Dzhalalova I.G., Tverdokhlebova D.K., Biryukova L.A., Shashin S.A., Kolesnikov V.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.astmedj.ru/jour/article/view/740">https://www.astmedj.ru/jour/article/view/740</self-uri><abstract><p>На сегодняшний день значение показателей общего анализа крови изучено у пациентов с онкопатологией и COVID-19, соматической патологией (артериальной гипертензией, сахарным диабетом) и COVID-19. Однако имеются пробелы в знаниях о значении показателей общего анализа крови у кардиохирургических пациентов и COVID-19. Цель. Изучить значение показателей общего анализа крови у пациентов, оперированных по поводу ишемической болезни сердца на фоне COVID-19. Материалы и методы. Были сформированы две группы пациентов, которые на дооперационном этапе были клинически, инструментально и лабораторно сопоставимы: 1-я группа – пациенты с ишемической болезнью сердца и COVID-19; 2-я группа – пациенты с ишемической болезнью сердца без COVID-19. Исследование показателей общего анализа крови проводили у всех пациентов на гематологическом анализаторе «Sysmex 2000 XN». Результаты. У пациентов с ишемической болезнью сердца и COVID-19 мы не выявили характерные для COVID-19 изменения в общем анализе крови: снижение количества эритроцитов, гемоглобина, тромбоцитов и лимфоцитов; повышение лейкоцитов и нейтрофилов. В то же время мы обнаружили увеличение показателей анизоцитоза эритроцитов и значений крупных тромбоцитов до появления клинических признаков COVID-19 ассоциированной пневмонии. Заключение. Показатели анизоцитоза эритроцитов и число крупных тромбоцитов могут быть использованы в качестве дополнительных критериев COVID-19 у пациентов, оперированных по поводу ишемической болезни сердца.</p></abstract><trans-abstract xml:lang="en"><p>To date, the value of general blood test parameters has been studied in patients with cancer and COVID-19, somatic pathologies (arterial hypertension, diabetes mellitus) and COVID-19. However, there are gaps in knowledge regarding the value of general blood test parameters in cardiac surgery patients and COVID-19. The aim. To study the significance of general blood test parameters in patients undergoing surgery for coronary heart disease associated with COVID-19. Materials and methods. Two groups of patients were formed, which were clinically, instrumentally and laboratory-comparable at the preoperative stage: Group 1 – patients with coronary heart disease and COVID-19; Group 2 – patients with coronary heart disease without COVID-19. A study of general blood test parameters was performed in all patients using the “Sysmex 2000 XN” hematological analyzer. The results. In patients with coronary heart disease and COVID-19, we did not detect any changes in the complete general blood test characteristic of COVID-19: decreased red blood cells, hemoglobin, platelet and lymphocyte counts; increased white blood cells and neutrophils counts. At the same time, we found an increase in erythrocyte anisocytosis indices and large platelet values before the onset of clinical signs of COVID-19 associated pneumonia. Conclusion. Erythrocyte anisocytosis indices and the number of large platelets can be used as additional criteria for COVID-19 in patients undergoing surgery for coronary heart disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>новая коронавирусная инфекция</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>общий анализ крови</kwd></kwd-group><kwd-group xml:lang="en"><kwd>new coronavirus infection</kwd><kwd>coronary heart disease</kwd><kwd>general blood test</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bolliger D., Mauermann E., Buser A. Preoperative anaemia in cardiac surgery: preoperative assessment, treatment and outcome // British Journal of Anaesthesia. 2022. Vol. 128, no. 4. P. 599–602. doi: 10.1016/j.bja.2021.12.049.</mixed-citation><mixed-citation xml:lang="en">Bolliger D., Mauermann E., Buser A. 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