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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">astmed</journal-id><journal-title-group><journal-title xml:lang="ru">Астраханский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Astrakhan medical journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1992-6499</issn><publisher><publisher-name>ФГБОУ ВО Астраханский ГМУ Минздрава России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17021/2020.15.2.13.23</article-id><article-id custom-type="elpub" pub-id-type="custom">astmed-74</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НАУЧНЫЕ ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SCIENTIFIC REVIEWS</subject></subj-group></article-categories><title-group><article-title>ОМИКСНЫЕ ТЕХНОЛОГИИ В ИЗУЧЕНИИ BACILLUS ANTHRACIS</article-title><trans-title-group xml:lang="en"><trans-title>OMICS TECHNOLOGIES IN THE STUDY OF BACILLUS ANTHRACIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Печковский</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pechkovskiy</surname><given-names>G. A.</given-names></name></name-alternatives><email xlink:type="simple">grigorii.pechkovskii@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тимченко</surname><given-names>Л. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Timchenko</surname><given-names>L. D.</given-names></name></name-alternatives><email xlink:type="simple">l_Timchenko@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Еременко</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Eremenko</surname><given-names>E. I.</given-names></name></name-alternatives><email xlink:type="simple">ejer@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ковалев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovalev</surname><given-names>D. A.</given-names></name></name-alternatives><email xlink:type="simple">kovalev_da.stv@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куличенко</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulichenko</surname><given-names>A. N.</given-names></name></name-alternatives><email xlink:type="simple">stavnipchi©mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФКУЗ «Ставропольский научно-исследовательский противочумный институт» Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Stavropol Research Anti-Plague Institute</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Северо-Кавказский федеральный университет»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>North-Caucasus Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>27</day><month>02</month><year>2023</year></pub-date><volume>15</volume><issue>2</issue><fpage>13</fpage><lpage>23</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Печковский Г.А., Тимченко Л.Д., Еременко Е.И., Ковалев Д.А., Куличенко А.Н., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Печковский Г.А., Тимченко Л.Д., Еременко Е.И., Ковалев Д.А., Куличенко А.Н.</copyright-holder><copyright-holder xml:lang="en">Pechkovskiy G.A., Timchenko L.D., Eremenko E.I., Kovalev D.A., Kulichenko A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.astmedj.ru/jour/article/view/74">https://www.astmedj.ru/jour/article/view/74</self-uri><abstract><p>Представлены результаты актуальных исследований возбудителя сибирской язвы, полученные с помощью омиксных технологий. Описаны основные достижения в области геномики, протеомики, транскриптомики, интерактомики, метаболомики Bacillus anthracis в результате применения омиксных технологий. Обсуждена связь развития омиксных технологий и биоинформатики, отражены дальнейшие перспективы и проблемы в этой области.</p></abstract><trans-abstract xml:lang="en"><p>This review presents the results of a current study of the anthrax pathogen obtained using omics technologies. The main achievements in the field of genomics, proteomics, transcriptomics, interaсtomics, and metabolomics of Bacillus anthracis as a result of the use of omics technologies are described. The connection of the development of omics technologies and bioinformatics are discussed; further prospects and problems in this area are reflected.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>омиксные технологии</kwd><kwd>геномика</kwd><kwd>транскриптомика</kwd><kwd>протеомика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Bacillus anthracis</kwd><kwd>Bacillus anthracis</kwd><kwd>“omics” technologies</kwd><kwd>genomics</kwd><kwd>transcriptomics</kwd><kwd>proteomics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Baggerman, G. Gel-based versus gel-free proteomics: a review / G. Baggerman, E. Vierstraete, A. De Loof, L. Schoofs // Combinatorial chemistry &amp; high throughput screening. - 2005. - Vol. 8, № 8. - P. 669-677.</mixed-citation><mixed-citation xml:lang="en">Baggerman, G. Gel-based versus gel-free proteomics: a review / G. Baggerman, E. Vierstraete, A. De Loof, L. Schoofs // Combinatorial chemistry &amp; high throughput screening. - 2005. - Vol. 8, № 8. - P. 669-677.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bergman, N. H. Murine macrophage transcriptional responses to Bacillus anthracis infection and intoxication / N. H. Bergman, K. D. Passalacqua, R. Gaspard, L. M. Shetron-Rama, J. Quackenbush, P. C. Hanna // Infection and immunity. - 2005. - Vol. 73, № 2. - P. 1069-1080.</mixed-citation><mixed-citation xml:lang="en">Bergman, N. H. Murine macrophage transcriptional responses to Bacillus anthracis infection and intoxication / N. H. Bergman, K. D. Passalacqua, R. Gaspard, L. M. Shetron-Rama, J. Quackenbush, P. C. Hanna // Infection and immunity. - 2005. - Vol. 73, № 2. - P. 1069-1080.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bergman, N. H. Transcriptional profiling of Bacillus anthracis during infection of host macrophages / N. H. Bergman, E. C. Anderson, E. E. Swenson, B. K. Janes, N. Fisher, M. M. Niemeyer, A. D. Miyoshi, P. C. Hanna // Infection and immunity. - 2007. - Vol. 75, № 7. - P. 3434-3444.</mixed-citation><mixed-citation xml:lang="en">Bergman, N. H. Transcriptional profiling of Bacillus anthracis during infection of host macrophages / N. H. Bergman, E. C. Anderson, E. E. Swenson, B. K. Janes, N. Fisher, M. M. Niemeyer, A. D. Miyoshi, P. C. Hanna // Infection and immunity. - 2007. - Vol. 75, № 7. - P. 3434-3444.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bergman, N. H. Transcriptional profiling of the Bacillus anthracis life cycle in vitro and an implied model for regulation of spore formation / N. H. Bergman, E. C. Anderson, E. E. Swenson, M. M. Niemeyer, A. D. Miyoshi, P. C. Hanna // Journal of bacteriology. - 2006. - Vol. 188, № 17. - P. 6092-6100.</mixed-citation><mixed-citation xml:lang="en">Bergman, N. H. Transcriptional profiling of the Bacillus anthracis life cycle in vitro and an implied model for regulation of spore formation / N. H. Bergman, E. C. Anderson, E. E. Swenson, M. M. Niemeyer, A. D. Miyoshi, P. C. Hanna // Journal of bacteriology. - 2006. - Vol. 188, № 17. - P. 6092-6100.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Booth, J. L. Gene expression profiling of primary human type I alveolar epithelial cells exposed to Bacillus anthracis spores reveals induction of neutrophil and monocyte chemokines / J. L. Booth, E. S. Duggan, V. I. Patel, W. Wu, D. M. Burian, D. C. Hutchings, V. L. White, K. M. Coggeshall, M. G. Dozmorov, J. P. Metcalf // Microbial pathogenesis. - 2018. - Vol. 121. - P. 9-21.</mixed-citation><mixed-citation xml:lang="en">Booth, J. L. Gene expression profiling of primary human type I alveolar epithelial cells exposed to Bacillus anthracis spores reveals induction of neutrophil and monocyte chemokines / J. L. Booth, E. S. Duggan, V. I. Patel, W. Wu, D. M. Burian, D. C. Hutchings, V. L. White, K. M. Coggeshall, M. G. Dozmorov, J. P. Metcalf // Microbial pathogenesis. - 2018. - Vol. 121. - P. 9-21.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Brown, P. O. Exploring the new world of the genome with DNA microarrays / P. O. Brown, D. Botstein // Nature genetics. - 1999. - Vol. 21, № 1. - P. 33-37.</mixed-citation><mixed-citation xml:lang="en">Brown, P. O. Exploring the new world of the genome with DNA microarrays / P. O. Brown, D. Botstein // Nature genetics. - 1999. - Vol. 21, № 1. - P. 33-37.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Carlson, P. E. Jr. Global gene expression by Bacillus anthracis during growth in mammalian blood / P. E. Jr. Carlson, A. E. T. Bourgis, A. K. Hagan, P. C. Hanna // Pathogens and disease. - 2015. - Vol. 73, № 8. doi: 10.1093/femspd/ftv061.</mixed-citation><mixed-citation xml:lang="en">Carlson, P. E. Jr. Global gene expression by Bacillus anthracis during growth in mammalian blood / P. E. Jr. Carlson, A. E. T. Bourgis, A. K. Hagan, P. C. Hanna // Pathogens and disease. - 2015. - Vol. 73, № 8. doi: 10.1093/femspd/ftv061.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Carlson, P. E. Jr. Transcriptional profiling of Bacillus anthracis Sterne (34F2) during iron starvation / P. E. Jr. Carlson, K. A. Carr, B. K. Janes, E. C. Anderson, P. C. Hanna // PLoS One. - 2009. - Vol. 4, № 9. - P. e 6988.</mixed-citation><mixed-citation xml:lang="en">Carlson, P. E. Jr. Transcriptional profiling of Bacillus anthracis Sterne (34F2) during iron starvation / P. E. Jr. Carlson, K. A. Carr, B. K. Janes, E. C. Anderson, P. C. Hanna // PLoS One. - 2009. - Vol. 4, № 9. - P. e 6988.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chenau, J. Identification and validation of specific markers of Bacillus anthracis spores by proteomics and genomics approaches / J. Chenau, F. Fenaille, V. Caro, M. Haustant, L. Diancourt, S. R. Klee, C. Junot, E. Ezan, P. L. Goossens, F. Becher // Molecular &amp; Cellular Proteomics. - 2014. - Vol. 13, № 3. - P. 716-732.</mixed-citation><mixed-citation xml:lang="en">Chenau, J. Identification and validation of specific markers of Bacillus anthracis spores by proteomics and genomics approaches / J. Chenau, F. Fenaille, V. Caro, M. Haustant, L. Diancourt, S. R. Klee, C. Junot, E. Ezan, P. L. Goossens, F. Becher // Molecular &amp; Cellular Proteomics. - 2014. - Vol. 13, № 3. - P. 716-732.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chitlaru, T. Differential proteomic analysis of the Bacillus anthracis secretome: distinct plasmid and chromosome CO2-dependent cross talk mechanisms modulate extracellular proteolytic activities / T. Chitlaru, O. Gat, Y. Gozlan, N. Ariel, A. Shafferman // Journal of bacteriology. - 2006. - Vol. 188, № 10. - P. 3551-3571.</mixed-citation><mixed-citation xml:lang="en">Chitlaru, T. Differential proteomic analysis of the Bacillus anthracis secretome: distinct plasmid and chromosome CO2-dependent cross talk mechanisms modulate extracellular proteolytic activities / T. Chitlaru, O. Gat, Y. Gozlan, N. Ariel, A. Shafferman // Journal of bacteriology. - 2006. - Vol. 188, № 10. - P. 3551-3571.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Chitlaru, T. Identification of in vivo-expressed immunogenic proteins by serological proteome analysis of the Bacillus anthracis secretome / T. Chitlaru, O. Gat, H. Grosfeld, I. Inbar, Y. Gozlan, A. Shafferman // Infection and immunity. - 2007. - Vol. 75, № 6. - P. 2841-2852.</mixed-citation><mixed-citation xml:lang="en">Chitlaru, T. Identification of in vivo-expressed immunogenic proteins by serological proteome analysis of the Bacillus anthracis secretome / T. Chitlaru, O. Gat, H. Grosfeld, I. Inbar, Y. Gozlan, A. Shafferman // Infection and immunity. - 2007. - Vol. 75, № 6. - P. 2841-2852.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Daligault, H. E. Twenty Whole-Genome Bacillus sp. Assemblies / H. E. Daligault, K. W. Davenport, T. D. Minogue, K. A. Bishop-Lilly, S. M. Broomall, D. C Bruce, P. S. Chain, S. R. Coyne, K. G. Frey, H. S. Gibbons, J. Jaissle, G. I. Koroleva, J. T. Ladner, C. C. Lo, C. Munk, G. F. Palacios, C. L. Redden, C. N. Rosenzweig, M. B. Scholz, S. L. Johnson // Genome Announc. - 2014. - Vol. 2, № 5. - P. e00958-14. doi: 10.1128/genomeA.00958-14.</mixed-citation><mixed-citation xml:lang="en">Daligault, H. E. Twenty Whole-Genome Bacillus sp. Assemblies / H. E. Daligault, K. W. Davenport, T. D. Minogue, K. A. Bishop-Lilly, S. M. Broomall, D. C Bruce, P. S. Chain, S. R. Coyne, K. G. Frey, H. S. Gibbons, J. Jaissle, G. I. Koroleva, J. T. Ladner, C. C. Lo, C. Munk, G. F. Palacios, C. L. Redden, C. N. Rosenzweig, M. B. Scholz, S. L. Johnson // Genome Announc. - 2014. - Vol. 2, № 5. - P. e00958-14. doi: 10.1128/genomeA.00958-14.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dozmorov, M. Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen / M. Dozmorov, W. Wu, K. Chakrabarty, J. L. Booth, R. E. Hurst, K. M. Coggeshall, J. P. Metcalf // BMC infectious diseases. - 2009. - Vol. 9, № 1. - P. 152.</mixed-citation><mixed-citation xml:lang="en">Dozmorov, M. Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen / M. Dozmorov, W. Wu, K. Chakrabarty, J. L. Booth, R. E. Hurst, K. M. Coggeshall, J. P. Metcalf // BMC infectious diseases. - 2009. - Vol. 9, № 1. - P. 152.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Dyer, M. D. The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis / M. D. Dyer, C Neff, M. Dufford, C. G. Rivera, D. Shattuck, J. Bassaganya-Riera, T. M. Murali, B. W. Sobral // PloS one. - 2010. - Vol. 5, № 8. - P. e 12089.doi: 10.1371/journal.pone.0012089.</mixed-citation><mixed-citation xml:lang="en">Dyer, M. D. The human-bacterial pathogen protein interaction networks of Bacillus anthracis, Francisella tularensis, and Yersinia pestis / M. D. Dyer, C Neff, M. Dufford, C. G. Rivera, D. Shattuck, J. Bassaganya-Riera, T. M. Murali, B. W. Sobral // PloS one. - 2010. - Vol. 5, № 8. - P. e 12089.doi: 10.1371/journal.pone.0012089.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Gohar, M. A comparative study of Bacillus cereus, Bacillus thuringiensis and Bacillus anthracis extracellular proteomes / M. Gohar, N. Gilois, R. Graveline, C. Garreau, V. Sanchis, D. Lereclus // Proteomics. - 2005. - Vol. 5, № 14. - P. 3696-3711.</mixed-citation><mixed-citation xml:lang="en">Gohar, M. A comparative study of Bacillus cereus, Bacillus thuringiensis and Bacillus anthracis extracellular proteomes / M. Gohar, N. Gilois, R. Graveline, C. Garreau, V. Sanchis, D. Lereclus // Proteomics. - 2005. - Vol. 5, № 14. - P. 3696-3711.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Guidi-Rontani, C. The alveolar macrophage: The Trojan horse of Bacillus anthracis / C. Guidi-Rontani // Trends in microbiology. - 2002. - Vol. 10, № 9. - P. 405-409.</mixed-citation><mixed-citation xml:lang="en">Guidi-Rontani, C. The alveolar macrophage: The Trojan horse of Bacillus anthracis / C. Guidi-Rontani // Trends in microbiology. - 2002. - Vol. 10, № 9. - P. 405-409.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Helgason, E. Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis-one species on the basis of genetic evidence / E. Helgason, O. A. Okstad, D. A. Caugant, H. A. Johansen, A. Fouet, M. Mock, I. Hegna, A. B. Kolstø // Appl. Environ. Microbiol. - 2000. - Vol. 66, № 6. - P. 2627-2630.</mixed-citation><mixed-citation xml:lang="en">Helgason, E. Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis-one species on the basis of genetic evidence / E. Helgason, O. A. Okstad, D. A. Caugant, H. A. Johansen, A. Fouet, M. Mock, I. Hegna, A. B. Kolstø // Appl. Environ. Microbiol. - 2000. - Vol. 66, № 6. - P. 2627-2630.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hoheisel, J. D. Microarray technology: beyond transcript profiling and genotype analysis / J. D. Hoheisel // Nature reviews genetics. - 2006. - Vol. 7, № 3. - P. 200-210.</mixed-citation><mixed-citation xml:lang="en">Hoheisel, J. D. Microarray technology: beyond transcript profiling and genotype analysis / J. D. Hoheisel // Nature reviews genetics. - 2006. - Vol. 7, № 3. - P. 200-210.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Humphrey, S. J. Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation / S. J. Humphrey, D. E. James, M. Mann // Trends in Endocrinology &amp; Metabolism. - 2015. - Vol. 26, № 12. - P. 676-687.</mixed-citation><mixed-citation xml:lang="en">Humphrey, S. J. Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation / S. J. Humphrey, D. E. James, M. Mann // Trends in Endocrinology &amp; Metabolism. - 2015. - Vol. 26, № 12. - P. 676-687.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson, S. L. Complete genome sequences for 35 biothreat assay-relevant bacillus species / S. L. Johnson, H. E. Daligault, K. W. Davenport, J. Jaissle, K. G. Frey, J. T. Ladner, S. M. Broomall, K. A. Bishop-Lilly, D. C. Bruce, H. S. Gibbons, S. R. Coyne, C. C. Lo, L. Meincke, A. C. Munk, G. I. Koroleva, C. N. Rosenzweig, G. F. Palacios, C. L. Redden, T. D. Minogue, P. S. Chain // Genome Announc. - 2015. - Vol. 3, № 2. - P. e00151-15.doi: 10.1128/genomeA.00151-15.</mixed-citation><mixed-citation xml:lang="en">Johnson, S. L. Complete genome sequences for 35 biothreat assay-relevant bacillus species / S. L. Johnson, H. E. Daligault, K. W. Davenport, J. Jaissle, K. G. Frey, J. T. Ladner, S. M. Broomall, K. A. Bishop-Lilly, D. C. Bruce, H. S. Gibbons, S. R. Coyne, C. C. Lo, L. Meincke, A. C. Munk, G. I. Koroleva, C. N. Rosenzweig, G. F. Palacios, C. L. Redden, T. D. Minogue, P. S. Chain // Genome Announc. - 2015. - Vol. 3, № 2. - P. e00151-15.doi: 10.1128/genomeA.00151-15.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Keim, P. Anthrax molecular epidemiology and forensics: using the appropriate marker for different evolutionary scales / P. Keim, M. N. Van Ert, T. Pearson, A. J. Vogler, L. Y. Huynh, D. M. Wagner // Infection, Genetics and Evolution. - 2004. - Vol. 4, № 3. - P. 205-213.</mixed-citation><mixed-citation xml:lang="en">Keim, P. Anthrax molecular epidemiology and forensics: using the appropriate marker for different evolutionary scales / P. Keim, M. N. Van Ert, T. Pearson, A. J. Vogler, L. Y. Huynh, D. M. Wagner // Infection, Genetics and Evolution. - 2004. - Vol. 4, № 3. - P. 205-213.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Keim, P. Molecular evolution and diversity in Bacillus anthracis as detected by amplified fragment length polymorphism markers / P. Keim, A. Kalif, J. Schupp, K. Hill, S. E. Travis, K. Richmond, D. M. Adair, M. Hugh-Jones, C. R. Kuske, P. Jackson // Journal of bacteriology. - 1997. - Vol. 179, № 3. - P. 818-824.</mixed-citation><mixed-citation xml:lang="en">Keim, P. Molecular evolution and diversity in Bacillus anthracis as detected by amplified fragment length polymorphism markers / P. Keim, A. Kalif, J. Schupp, K. Hill, S. E. Travis, K. Richmond, D. M. Adair, M. Hugh-Jones, C. R. Kuske, P. Jackson // Journal of bacteriology. - 1997. - Vol. 179, № 3. - P. 818-824.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Keim, P. Multiple-locus variable-number tandem repeat analysis reveals genetic relationships within Bacillus anthracis / P. Keim, L. B. Price, A. M. Klevytska, K. L. Smith, J. M. Schupp, R. Okinaka, P. J. Jackson, M. E. Hugh-Jones // Journal of bacteriology. - 2000. - Vol. 182, № 10. - P. 2928-2936.</mixed-citation><mixed-citation xml:lang="en">Keim, P. Multiple-locus variable-number tandem repeat analysis reveals genetic relationships within Bacillus anthracis / P. Keim, L. B. Price, A. M. Klevytska, K. L. Smith, J. M. Schupp, R. Okinaka, P. J. Jackson, M. E. Hugh-Jones // Journal of bacteriology. - 2000. - Vol. 182, № 10. - P. 2928-2936.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Lamonica, J. M. Comparative secretome analyses of three Bacillus anthracis strains with variant plasmid contents / J. M. Lamonica, M. Wagner, M. Eschenbrenner, L. E. Williams, T. L. Miller, G. Patra, V. G. DelVecchio // Infection and immunity. - 2005. - Vol. 73, № 6. - P. 3646-3658.</mixed-citation><mixed-citation xml:lang="en">Lamonica, J. M. Comparative secretome analyses of three Bacillus anthracis strains with variant plasmid contents / J. M. Lamonica, M. Wagner, M. Eschenbrenner, L. E. Williams, T. L. Miller, G. Patra, V. G. DelVecchio // Infection and immunity. - 2005. - Vol. 73, № 6. - P. 3646-3658.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Langel, F. D. Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns / F. D. Langel, C. Y. Chiang, D. Lane, T. Kenny, J. F. Ojeda, Y. Zhong, J. Che, Y. Zhou, W. Ribot, K. P. Kota, S. Bavari, R. G. Panchal // PloS one. - 2014. - Vol. 9, № 2. - P. e 87201. doi: 10.1371/journal.pone.0087201.</mixed-citation><mixed-citation xml:lang="en">Langel, F. D. Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns / F. D. Langel, C. Y. Chiang, D. Lane, T. Kenny, J. F. Ojeda, Y. Zhong, J. Che, Y. Zhou, W. Ribot, K. P. Kota, S. Bavari, R. G. Panchal // PloS one. - 2014. - Vol. 9, № 2. - P. e 87201. doi: 10.1371/journal.pone.0087201.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Liu, H. Formation and composition of the Bacillus anthracis endospore / H. Liu, N. H. Bergman, B. Thomason, S. Shallom, A. Hazen, J. Crossno, D. A. Rasko, J. Ravel, T. D. Read, S. N. Peterson, J. 3rd Yates, P. C. Hanna // Journal of bacteriology. - 2004. - Vol. 186, № 1. - P. 164-178.</mixed-citation><mixed-citation xml:lang="en">Liu, H. Formation and composition of the Bacillus anthracis endospore / H. Liu, N. H. Bergman, B. Thomason, S. Shallom, A. Hazen, J. Crossno, D. A. Rasko, J. Ravel, T. D. Read, S. N. Peterson, J. 3rd Yates, P. C. Hanna // Journal of bacteriology. - 2004. - Vol. 186, № 1. - P. 164-178.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Manes, N. P. Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry / N. P. Manes, L Dong, W Zhou, X Du, N Reghu, A. C. Kool, D. Choi, C. L. Bailey, E. F. 3rd Petricoin, L. A. Liotta, S. G. Popov // Molecular &amp; Cellular Proteomics. - 2011. - Vol. 10, № 3.doi: 10.1074/mcp.M110.000927.</mixed-citation><mixed-citation xml:lang="en">Manes, N. P. Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry / N. P. Manes, L Dong, W Zhou, X Du, N Reghu, A. C. Kool, D. Choi, C. L. Bailey, E. F. 3rd Petricoin, L. A. Liotta, S. G. Popov // Molecular &amp; Cellular Proteomics. - 2011. - Vol. 10, № 3.doi: 10.1074/mcp.M110.000927.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Martin, J. Bacillus anthracis genome organization in light of whole transcriptome sequencing / J. Martin, W. Zhu, K. D. Passalacqua, N. Bergman, M. Borodovsky // BMC bioinformatics. - BioMed Central, 2010. - Vol. 11, № S3. - P. S10.doi: 10.1186/1471-2105-11-S3-S10.</mixed-citation><mixed-citation xml:lang="en">Martin, J. Bacillus anthracis genome organization in light of whole transcriptome sequencing / J. Martin, W. Zhu, K. D. Passalacqua, N. Bergman, M. Borodovsky // BMC bioinformatics. - BioMed Central, 2010. - Vol. 11, № S3. - P. S10.doi: 10.1186/1471-2105-11-S3-S10.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen, C. T. Global metabolomic analysis of a mammalian host infected with Bacillus anthracis / C. T. Nguyen, V. Shetty, A. W. Maresso // Infection and immunity. - 2015. - Vol. 83, № 12. - P. 4811-4825.</mixed-citation><mixed-citation xml:lang="en">Nguyen, C. T. Global metabolomic analysis of a mammalian host infected with Bacillus anthracis / C. T. Nguyen, V. Shetty, A. W. Maresso // Infection and immunity. - 2015. - Vol. 83, № 12. - P. 4811-4825.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ogawa, H. A novel multiplex PCR discriminates Bacillus anthracis and its genetically related strains from other Bacillus cereus group species / H. Ogawa, D. Fujikura, M. Ohnuma, N. Ohnishi, B. M. Hang'ombe, H. Mimuro, T. Ezaki, A. S. Mweene, H. Higashi // PLoS One. - 2015. - Vol. 10, № 3. - P. e 0122004.doi: 10.1371/journal.pone.0122004.</mixed-citation><mixed-citation xml:lang="en">Ogawa, H. A novel multiplex PCR discriminates Bacillus anthracis and its genetically related strains from other Bacillus cereus group species / H. Ogawa, D. Fujikura, M. Ohnuma, N. Ohnishi, B. M. Hang'ombe, H. Mimuro, T. Ezaki, A. S. Mweene, H. Higashi // PLoS One. - 2015. - Vol. 10, № 3. - P. e 0122004.doi: 10.1371/journal.pone.0122004.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Passalacqua, K. D. Comparative transcriptional profiling of Bacillus cereus sensu lato strains during growth in CO2-bicarbonate and aerobic atmospheres / K. D. Passalacqua, A. Varadarajan, B. Byrd, N. H. Bergman // PloS one. - 2009. - Vol. 4, № 3. - P. e 4904.doi: 10.1371/journal.pone.0004904.</mixed-citation><mixed-citation xml:lang="en">Passalacqua, K. D. Comparative transcriptional profiling of Bacillus cereus sensu lato strains during growth in CO2-bicarbonate and aerobic atmospheres / K. D. Passalacqua, A. Varadarajan, B. Byrd, N. H. Bergman // PloS one. - 2009. - Vol. 4, № 3. - P. e 4904.doi: 10.1371/journal.pone.0004904.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Passalacqua, K. D. Strand-specific RNA-seq reveals ordered patterns of sense and antisense transcription in Bacillus anthracis / K. D. Passalacqua, A. Varadarajan, C. Weist, B. D. Ondov, B. Byrd, T. D. Read, N. H. Bergman // PLoS One. - 2012. - Vol. 7, № 8. - P. e 43350.doi: 10.1371/journal.pone.0043350.</mixed-citation><mixed-citation xml:lang="en">Passalacqua, K. D. Strand-specific RNA-seq reveals ordered patterns of sense and antisense transcription in Bacillus anthracis / K. D. Passalacqua, A. Varadarajan, C. Weist, B. D. Ondov, B. Byrd, T. D. Read, N. H. Bergman // PLoS One. - 2012. - Vol. 7, № 8. - P. e 43350.doi: 10.1371/journal.pone.0043350.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Passalacqua, K. D. Structure and complexity of a bacterial transcriptome / K. D. Passalacqua, A. Varadarajan, B. D. Ondov, D. T. Okou, M. E. Zwick, N. H. Bergman// Journal of bacteriology. - 2009. - Vol. 191, № 10. - P. 3203-3211.</mixed-citation><mixed-citation xml:lang="en">Passalacqua, K. D. Structure and complexity of a bacterial transcriptome / K. D. Passalacqua, A. Varadarajan, B. D. Ondov, D. T. Okou, M. E. Zwick, N. H. Bergman// Journal of bacteriology. - 2009. - Vol. 191, № 10. - P. 3203-3211.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Passalacqua, K. D. The global transcriptional responses of Bacillus anthracis Sterne (34F2) and a ΔsodA1 mutant to paraquat reveal metal ion homeostasis imbalances during endogenous superoxide stress / K. D. Passalacqua, N. H. Bergman, J. Y. Lee, D. H. Sherman, P. C. Hanna // Journal of bacteriology. - 2007. - Vol. 189, № 11. - P. 3996-4013.</mixed-citation><mixed-citation xml:lang="en">Passalacqua, K. D. The global transcriptional responses of Bacillus anthracis Sterne (34F2) and a ΔsodA1 mutant to paraquat reveal metal ion homeostasis imbalances during endogenous superoxide stress / K. D. Passalacqua, N. H. Bergman, J. Y. Lee, D. H. Sherman, P. C. Hanna // Journal of bacteriology. - 2007. - Vol. 189, № 11. - P. 3996-4013.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Pearson, T. Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing / T. Pearson, J. D. Busch, J. Ravel, T. D. Read, S. D. Rhoton, J. M. U'Ren, T. S. Simonson, S. M. Kachur, R. R. Leadem, M. L. Cardon, M. N. Van Ert, L. Y. Huynh, C. M. Fraser, P. Keim // Proceedings of the National Academy of Sciences. - 2004. - Vol. 101, № 37. - P. 13536-13541.</mixed-citation><mixed-citation xml:lang="en">Pearson, T. Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing / T. Pearson, J. D. Busch, J. Ravel, T. D. Read, S. D. Rhoton, J. M. U'Ren, T. S. Simonson, S. M. Kachur, R. R. Leadem, M. L. Cardon, M. N. Van Ert, L. Y. Huynh, C. M. Fraser, P. Keim // Proceedings of the National Academy of Sciences. - 2004. - Vol. 101, № 37. - P. 13536-13541.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Ravel, J. The complete genome sequence of Bacillus anthracis Ames “Ancestor” / J. Ravel, L. Jiang, S. T. Stanley, M. R. Wilson, R. S. Decker, T. D. Read, P. Worsham, P. S. Keim, S. L. Salzberg, C. M. Fraser-Liggett, D. A. Rasko // Journal of bacteriology. - 2009. - Vol. 191, № 1. - P. 445-446.</mixed-citation><mixed-citation xml:lang="en">Ravel, J. The complete genome sequence of Bacillus anthracis Ames “Ancestor” / J. Ravel, L. Jiang, S. T. Stanley, M. R. Wilson, R. S. Decker, T. D. Read, P. Worsham, P. S. Keim, S. L. Salzberg, C. M. Fraser-Liggett, D. A. Rasko // Journal of bacteriology. - 2009. - Vol. 191, № 1. - P. 445-446.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Read, T. D. Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis / T. D. Read, S. L. Salzberg, M. Pop, M. Shumway, L. Umayam, L. Jiang, E. Holtzapple, J. D. Busch, K. L. Smith, J. M. Schupp, D. Solomon, P. Keim, C. M. Fraser // Science. - 2002. - Vol. 296, № 5575. - P. 2028-2033.</mixed-citation><mixed-citation xml:lang="en">Read, T. D. Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis / T. D. Read, S. L. Salzberg, M. Pop, M. Shumway, L. Umayam, L. Jiang, E. Holtzapple, J. D. Busch, K. L. Smith, J. M. Schupp, D. Solomon, P. Keim, C. M. Fraser // Science. - 2002. - Vol. 296, № 5575. - P. 2028-2033.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Read, T. D. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria / T. D. Read, S. N. Peterson, N. Tourasse, L. W. Baillie, I. T. Paulsen, K. E. Nelson, H. Tettelin, D. E. Fouts, J. A. Eisen, S. R. Gill, E. K. Holtzapple, O. A. Okstad, E. Helgason, J. Rilstone, M. Wu, J. F. Kolonay, M. J. Beanan, R. J. Dodson, L. M. Brinkac, M. Gwinn, R. T. DeBoy, R. Madpu, S. C. Daugherty, A. S. Durkin, D. H. Haft, W. C. Nelson, J. D. Peterson, M. Pop, H. M. Khouri, D. Radune, J. L. Benton, Y. Mahamoud, L. Jiang, I. R. Hance, J. F. Weidman, K. J. Berry, R. D. Plaut, A. M. Wolf, K. L. Watkins, W. C. Nierman, A. Hazen, R. Cline, C. Redmond, J. E. Thwaite, O. White, S. L. Salzberg, B. Thomason, A. M. Friedlander, T. M. Koehler, P. C. Hanna, A. B. Kolstø, C. M. Fraser // Nature. - 2003. - Vol. 423, № 6935. - P. 81-86.</mixed-citation><mixed-citation xml:lang="en">Read, T. D. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria / T. D. Read, S. N. Peterson, N. Tourasse, L. W. Baillie, I. T. Paulsen, K. E. Nelson, H. Tettelin, D. E. Fouts, J. A. Eisen, S. R. Gill, E. K. Holtzapple, O. A. Okstad, E. Helgason, J. Rilstone, M. Wu, J. F. Kolonay, M. J. Beanan, R. J. Dodson, L. M. Brinkac, M. Gwinn, R. T. DeBoy, R. Madpu, S. C. Daugherty, A. S. Durkin, D. H. Haft, W. C. Nelson, J. D. Peterson, M. Pop, H. M. Khouri, D. Radune, J. L. Benton, Y. Mahamoud, L. Jiang, I. R. Hance, J. F. Weidman, K. J. Berry, R. D. Plaut, A. M. Wolf, K. L. Watkins, W. C. Nierman, A. Hazen, R. Cline, C. Redmond, J. E. Thwaite, O. White, S. L. Salzberg, B. Thomason, A. M. Friedlander, T. M. Koehler, P. C. Hanna, A. B. Kolstø, C. M. Fraser // Nature. - 2003. - Vol. 423, № 6935. - P. 81-86.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Riojas, M. A. Multiplex PCR for species-level identification of Bacillus anthracis and detection of pXO1, pXO2, and related plasmids / M. A. Riojas, K. Kiss, M. L. McKee, M. H. Hazbón // Health security. - 2015. - Vol. 13, № 2. - P. 122-129.</mixed-citation><mixed-citation xml:lang="en">Riojas, M. A. Multiplex PCR for species-level identification of Bacillus anthracis and detection of pXO1, pXO2, and related plasmids / M. A. Riojas, K. Kiss, M. L. McKee, M. H. Hazbón // Health security. - 2015. - Vol. 13, № 2. - P. 122-129.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Seo, G. M. Bacillus anthracis spores influence ATP synthase activity in murine macrophages / G. M. Seo, K. H. Jung, S. J. Kim, J. C. Kim, J. W. Yoon, K. K. Oh, J. H. Lee, Y. G. Chai // Journal of microbiology and biotechnology. - 2008. - Vol. 18, № 4. - P. 778-783.</mixed-citation><mixed-citation xml:lang="en">Seo, G. M. Bacillus anthracis spores influence ATP synthase activity in murine macrophages / G. M. Seo, K. H. Jung, S. J. Kim, J. C. Kim, J. W. Yoon, K. K. Oh, J. H. Lee, Y. G. Chai // Journal of microbiology and biotechnology. - 2008. - Vol. 18, № 4. - P. 778-783.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Seo G. M. Targeting of Bacillus anthracis interaction factors for human macrophages using two-dimensional gel electrophoresis / G. M. Seo, S. J. Kim, J. C. Kim, D. H. Nam, M. Y. Yoon, B. S. Koo, Y. G. Chai // Biochemical and biophysical research communications. - 2004. - Vol. 322, № 3. - P. 854-859.</mixed-citation><mixed-citation xml:lang="en">Seo G. M. Targeting of Bacillus anthracis interaction factors for human macrophages using two-dimensional gel electrophoresis / G. M. Seo, S. J. Kim, J. C. Kim, D. H. Nam, M. Y. Yoon, B. S. Koo, Y. G. Chai // Biochemical and biophysical research communications. - 2004. - Vol. 322, № 3. - P. 854-859.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Spratlin, J. L. Clinical applications of metabolomics in oncology: a review / J. L. Spratlin, N. J. Serkova, S. G. Eckhardt // Clinical cancer research. - 2009. - Vol. 15, № 2. - P. 431-440.</mixed-citation><mixed-citation xml:lang="en">Spratlin, J. L. Clinical applications of metabolomics in oncology: a review / J. L. Spratlin, N. J. Serkova, S. G. Eckhardt // Clinical cancer research. - 2009. - Vol. 15, № 2. - P. 431-440.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Van Ert, M. N. Global genetic population structure of Bacillus anthracis / M. N. Van Ert, W. R. Easterday, L. Y. Huynh, R. T. Okinaka, M. E. Hugh-Jones, J. Ravel, S. R. Zanecki, T. Pearson, T. S. Simonson, J. M. U'Ren, S. M. Kachur, R. R. Leadem-Dougherty, S. D. Rhoton, G. Zinser, J. Farlow, P. R. Coker, K. L. Smith, B. Wang, L. J. Kenefic, C. M. Fraser-Liggett, D. M. Wagner, P. Keim // PloS one. - 2007. - Vol. 2, № 5. - P. e 461.doi: 10.1371/journal.pone.0000461.</mixed-citation><mixed-citation xml:lang="en">Van Ert, M. N. Global genetic population structure of Bacillus anthracis / M. N. Van Ert, W. R. Easterday, L. Y. Huynh, R. T. Okinaka, M. E. Hugh-Jones, J. Ravel, S. R. Zanecki, T. Pearson, T. S. Simonson, J. M. U'Ren, S. M. Kachur, R. R. Leadem-Dougherty, S. D. Rhoton, G. Zinser, J. Farlow, P. R. Coker, K. L. Smith, B. Wang, L. J. Kenefic, C. M. Fraser-Liggett, D. M. Wagner, P. Keim // PloS one. - 2007. - Vol. 2, № 5. - P. e 461.doi: 10.1371/journal.pone.0000461.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Vitzthum, F. Proteomics: from basic research to diagnostic application. A review of requirements &amp; needs / F. Vitzthum, F. Behrens, N. L. Anderson, J. H. Shaw // Journal of proteome research. - 2005. - Vol. 4, № 4. - P. 1086-1097.</mixed-citation><mixed-citation xml:lang="en">Vitzthum, F. Proteomics: from basic research to diagnostic application. A review of requirements &amp; needs / F. Vitzthum, F. Behrens, N. L. Anderson, J. H. Shaw // Journal of proteome research. - 2005. - Vol. 4, № 4. - P. 1086-1097.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Wang, Z. RNA-Seq: a revolutionary tool for transcriptomics / Z. Wang, M. Gerstein, M. Snyder // Nature reviews genetics. - 2009. - Vol. 10, № 1. - P. 57-63.</mixed-citation><mixed-citation xml:lang="en">Wang, Z. RNA-Seq: a revolutionary tool for transcriptomics / Z. Wang, M. Gerstein, M. Snyder // Nature reviews genetics. - 2009. - Vol. 10, № 1. - P. 57-63.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Wunschel, D. S. Proteomic signatures differentiating Bacillus anthracis Sterne sporulation on soil relative to laboratory media / D. S. Wunschel, J. R. Hutchison, B. L. Deatherage Kaiser, E. D. Merkley, B. M. Hess, A. Lin, M. G. Warner // Analyst. - 2018. - Vol. 143, № 1. - P. 123-132.</mixed-citation><mixed-citation xml:lang="en">Wunschel, D. S. Proteomic signatures differentiating Bacillus anthracis Sterne sporulation on soil relative to laboratory media / D. S. Wunschel, J. R. Hutchison, B. L. Deatherage Kaiser, E. D. Merkley, B. M. Hess, A. Lin, M. G. Warner // Analyst. - 2018. - Vol. 143, № 1. - P. 123-132.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Zhong, W. Differentiation of Bacillus anthracis, B. cereus, and B. thuringiensis by using pulsed-field gel electrophoresis / W. Zhong, Y. Shou, T. M. Yoshida, B. L. Marrone // Appl. Environ. Microbiol. - 2007. - Vol. 73, № 10. - P. 3446-3449.</mixed-citation><mixed-citation xml:lang="en">Zhong, W. Differentiation of Bacillus anthracis, B. cereus, and B. thuringiensis by using pulsed-field gel electrophoresis / W. Zhong, Y. Shou, T. M. Yoshida, B. L. Marrone // Appl. Environ. Microbiol. - 2007. - Vol. 73, № 10. - P. 3446-3449.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
