astmedАстраханский медицинский журналAstrakhan medical journal1992-6499ФГБОУ ВО Астраханский ГМУ Минздрава России10.17021/1992-6499-2026-1-27-33astmed-679Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSРоль мелатонина в репродуктивном здоровье женщинMelatonin in the Context of Women's Healthhttps://orcid.org/0000-0001-9459-5698НиколаеваМ. Г.NikolaevaM. G.

Мария Геннадьевна Николаева, доктор медицинских наук, профессор, профессор кафедры акушерства и гинекологии;

врач акушер-гинеколог

Барнаул

Maria G. Nikolaeva, Dr. Sci. (Med), Professor, Professor of the Department;

Obstetrician-Gynecologist

Barnaul

nikolmg@yandex.ruhttps://orcid.org/0000-0001-6990-0515УвароваЮ. М.UvarovaYu. M.

Юлия Михайловна Уварова, врач акушер-гинеколог

Барнаул

Yulia M. Uvarova, Obstetrician-Gynecologist

Barnaul

Jugenic@rambler.ruhttps://orcid.org/0000-0001-5763-4969ГорбачеваТ. И.GorbachevaT. I.

Татьяна Ивановна Горбачева, кандидат медицинских наук, доцент, доцент кафедры акушерства и гинекологии;

врач акушер-гинеколог

Барнаул

Tatiana I. Gorbacheva, Cand. Sci. (Med), Associate Professor, Associate Professor of the Department;

Obstetrician-Gynecologist

Barnaul

tg72@bk.ruАлтайский государственный медицинский университет; РЖД-МедицинаРоссияAltai State Medical University; RZD-MedicineRussian FederationКонсультативно-диагностический центр Алтайского краяРоссияConsulting and Diagnostic Center of the Altai TerritoryRussian FederationАлтайский государственный медицинский университет; Краевая клиническая больница скорой медицинской помощиРоссияAltai State Medical University; Regional Clinical Hospital for Emergency Medical CareRussian Federation2026160420262112733Copyright © Николаева М.Г., Уварова Ю.М., Горбачева Т.И., 20262026Николаева М.Г., Уварова Ю.М., Горбачева Т.И.Nikolaeva M.G., Uvarova Y.M., Gorbacheva T.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.astmedj.ru/jour/article/view/679

В статье представлены результаты исследований зарубежных и отечественных авторов, касающиеся роли мелатонина в репродуктивном здоровье женщин. Мелатонин (N-ацетил-5-метокситриптамин) – основной гормон эпифиза, обладающий широким спектром биологических эффектов, таких как антиоксидантное, иммуномодулирующее, онкопротективное, антидепрессантное, противосудорожное, гипохолестеринемическое и гипогликемическое действия. В репродуктивной системе он способствует созреванию фолликулов, гаметогенезу, оплодотворению и имплантации эмбриона, защищая половые клетки и хориальную ткань от свободных радикалов. Систематизация имеющихся сведений позволит обосновать необходимость исследования биомаркера при дисфункции репродуктивной системы, в частности при вторичной функциональной олигоменорее.

The article presents the results of research by foreign and domestic authors on the role of melatonin in women's reproductive health. Melatonin (N-acetyl-5-methoxytryptamine) is the main hormone of the pineal gland and has a wide range of biological effects, including antioxidant, immunomodulatory, cancer-protective, antidepressant, anticonvulsant, hypocholesterolemic, and hypoglycemic effects. In the reproductive system, it promotes follicular maturation, gametogenesis, fertilization, and embryo implantation, protecting reproductive cells and chorionic tissue from free radicals. By systematizing existing knowledge, it will be possible to justify the need for research on biomarkers in reproductive system dysfunction, particularly in secondary functional oligomenorrhea.

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The authors declare that there are no conflicts of interest present.