astmedАстраханский медицинский журналAstrakhan medical journal1992-6499ФГБОУ ВО Астраханский ГМУ Минздрава России10.17021/1992-6499-2025-3-6-16astmed-607Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSРезистентность к метронидазолу: характеристика проблемы, пути преодоленияResistance to metronidazole: characteristics of the problem, ways to overcomehttps://orcid.org/0000-0002-6955-1025КругловЕ. Е.KruglovE. E.

Круглов Егор Евгеньевич, кандидат медицинских наук, научный сотрудник, Государственный научно-исследовательский испытательный институт военной медицины, Санкт-Петербург, Россия; доцент кафедры клинической медицины, Университет «Реавиз»

Санкт-Петербург

Egor E. Kruglov, Cand. Sci. (Med.), Researcher, State Research and Testing Military Medical Institute, St. Petersburg, Russia; Associate Professor, Department of Clinical Medicine at Reaviz University

St. Petersburg

krugegr@rambler.ruhttps://orcid.org/0000-0001-5646-0880ЮдинМ. А.YudinM. A.

Юдин Михаил Анатольевич, доктор медицинских наук, профессор, начальник центр

Санкт-Петербург

Mikhail A. Yudin, Dr. Sci. (Med.), Professor, Head of the Center

St. Petersburg

gniiivm_2@mil.ruhttps://orcid.org/0009-0001-7342-7721АнохинА. Г.AnokhinA. G.

Анохин Александр Геннадьевич, кандидат медицинских наук, начальник управления

Санкт-Петербург

Alexander G. Anohin, Cand. Sci. (Med.), Head of the Department

St. Petersburg

gniiivm_2@mil.ruГосударственный научно-исследовательский испытательный институт военной медицины; Университет «Реавиз»РоссияState Research and Testing Institute of Military Medicine; Reaviz UniversityRussian FederationГосударственный научно-исследовательский испытательный институт военной медициныРоссияState Research and Testing Institute of Military MedicineRussian Federation202529112025203616Copyright © Круглов Е.Е., Юдин М.А., Анохин А.Г., 20252025Круглов Е.Е., Юдин М.А., Анохин А.Г.Kruglov E.E., Yudin M.A., Anokhin A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.astmedj.ru/jour/article/view/607

На примере метронидазола систематизированы современные достижения науки в области открытия новых механизмов развития устойчивости бактерий и простейших к антибактериальным препаратам. На молекулярном уровне рассмотрена эпигенетическая вариабельность развития резистентности к метронидазолу, а также ее протеомная составляющая в ряду лиганд-фермент-субстрат-ассоциированной специфичности взаимодействия. На экспериментальных моделях со штаммами бактерий показаны перспективы преодоления механизмов антибиотикорезистентности с использованием современных наноматериалов и металлорганических каркасных полимеров. Отмечена возможность подбора условий и матрицы металлорганических каркасных полимеров для достижения адресной доставки лекарственных средств. Применение наноматериалов позволяет потенцировать эффект антибактериального препарата.

Using the example of metronidazole, modern scientific achievements in the field of discovering new mechanisms for the development of resistance of bacteria and protozoa to antibacterial drugs are systematized. At the molecular level, the epigenetic variability of the development of resistance to metronidazole, as well as its proteomic component in the series of ligand-enzyme-substrate-associated specificity of interaction, is considered. Experimental models with bacterial strains show the prospects of overcoming the mechanisms of antibiotic resistance using modern nanomaterials and organometallic framework polymers. The possibility of selecting conditions and a matrix of metalorganic framework polymers to achieve targeted drug delivery is noted. The use of nanomaterials makes it possible to potentiate the effect of an anti-bacterial drug.

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The authors declare that there are no conflicts of interest present.