astmedАстраханский медицинский журналAstrakhan medical journal1992-6499ФГБОУ ВО Астраханский ГМУ Минздрава России10.17021/2020.15.1.6.9astmed-60Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL INVESTIGATIONSIS PIVKA-II A PROMISING BIOMARKER FOR HEPATOCELLULAR CARCINOMA?BrozP.brozp@fnplzen.czSvobodovaS.sarka.svobodova@lf1.cuni.czKarlíkovaM.karlikovam@fnplzen.czTopolcanO.topolcan@fnplzen.czTreskaV.treska@fnplzen.czKuceraR.kucerar@fnplzen.czUniversity Hospital and Faculty of Medicine in Pilsen, Charles University; Institute of Clinical Biochemistry and Haematology, University Hospital in PilsenRussian FederationUniversity Hospital and Faculty of Medicine in Pilsen, Charles UniversityRussian Federation20202702202315169Copyright © Broz P., Svobodova S., Karlíkova M., Topolcan O., Treska V., Kucera R., 20232023Broz P., Svobodova S., Karlíkova M., Topolcan O., Treska V., Kucera R.Broz P., Svobodova S., Karlíkova M., Topolcan O., Treska V., Kucera R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.astmedj.ru/jour/article/view/60

Aim. To evaluate the clinical contribution of protein induced by vitamin K absence (PIVKA-II) for the diagnosis of hepatocellular carcinoma (HCC). The second aim was to compare PIVKA-II with routinely used alpha-fetoprotein (AFP) for the same indication. Materials and methods. 310 participants were enrolled in our study: 60 with HCC, 40 with liver metastases of colorectal cancer origin, 40 with liver cirrhosis, 20 with pancreatic cancer (PC) and 150 healthy individuals. Serum levels of PIVKA-II were measured using a chemiluminescent assay of the Architect 1000i System (“Abbott”, USA) and AFP levels using a chemiluminescent assay by DxI 800 (“Beckman Coulter”, USA). Serum concentrations of PIVKA-II and AFP were compared between the group with HCC and the other mentioned groups. Results. PIVKA-II achieved better clinical sensitivity in comparison with AFP. PIVKA-II achieved its best sensitivity (96,9 %) in distinguishing between the HCC and control group with the proposed cut-off value of 60 mAU/ml. Conclusion. PIVKA-II can be used alongside routinely established AFP as a valuable marker in the diagnosis of HCC.

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The authors declare that there are no conflicts of interest present.