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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">astmed</journal-id><journal-title-group><journal-title xml:lang="ru">Астраханский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Astrakhan medical journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1992-6499</issn><publisher><publisher-name>ФГБОУ ВО Астраханский ГМУ Минздрава России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17021/2019.14.4.68.73</article-id><article-id custom-type="elpub" pub-id-type="custom">astmed-56</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДОСТИЖЕНИЯ НАУКИ В ПРАКТИКУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACHIEVEMENTS OF SCIENCE IN PRACTICE</subject></subj-group></article-categories><title-group><article-title>СИСТЕМЫ МУКОЗАЛЬНЫХ ЛЕКТИНОВ ДЛЯ МЕДИЦИНСКИХ ТЕХНОЛОГИЙ (КРАТКИЙ АНАЛИЗ)</article-title><trans-title-group xml:lang="en"><trans-title>SYSTEMS OF THE MUCOSAL LECTINS FOR MEDICAL TECHNOLOGIES (BRIEF ANALYSIS)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лахтин</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lakhtin</surname><given-names>V. M.</given-names></name></name-alternatives><email xlink:type="simple">info@gabrich.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алешкин</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Aleshkin</surname><given-names>V. A.</given-names></name></name-alternatives><email xlink:type="simple">info@gabrich.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лахтин</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lakhtin</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">info@gabrich.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Афанасьев</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Afanas’Iev</surname><given-names>S. S.</given-names></name></name-alternatives><email xlink:type="simple">afanasievss409.4@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пчелинцев</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Pchelintsev</surname><given-names>S. Yu.</given-names></name></name-alternatives><email xlink:type="simple">serg.pch@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanov</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">stepanovav@petrovax.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриев</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitriev</surname><given-names>G. A.</given-names></name></name-alternatives><email xlink:type="simple">academicdmitriev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Леонтьева</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Leontieva</surname><given-names>N. I.</given-names></name></name-alternatives><email xlink:type="simple">leonteva-nina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грачева</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gracheva</surname><given-names>N. M.</given-names></name></name-alternatives><email xlink:type="simple">leonteva-nina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шмелева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shmeleva</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">lab4521814@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мануйлов</surname><given-names>Б. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Manuilov</surname><given-names>B. M.</given-names></name></name-alternatives><email xlink:type="simple">bmanuilov@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эйберман</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Eyberman</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">aberman@bk.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБУН «Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского» Роспотребнадзора</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Epidemiology and Microbiology n. a. N.G. Gabrichevsky</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ОАО «Институт инженерной иммунологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute for Immunological Engineering</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ООО «НПО Петровакс Фарм»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>NPO Petrovax Pharm</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>НИИ детского питания - филиал ФГБУН «ФИЦ питания и биотехнологии»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Child Nutrition Research Institute - Branch of Federal Publicly Funded Institution of Science “Federal Research Center of Nutrition and Biotechnology”</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБОУ ВО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saratov State Medical University named after V.I. Razumovsky</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>27</day><month>02</month><year>2023</year></pub-date><volume>14</volume><issue>4</issue><fpage>68</fpage><lpage>73</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лахтин В.М., Алешкин В.А., Лахтин М.В., Афанасьев С.С., Пчелинцев С.Ю., Степанов А.В., Дмитриев Г.А., Леонтьева Н.И., Грачева Н.М., Шмелева Е.А., Мануйлов Б.М., Эйберман А.С., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Лахтин В.М., Алешкин В.А., Лахтин М.В., Афанасьев С.С., Пчелинцев С.Ю., Степанов А.В., Дмитриев Г.А., Леонтьева Н.И., Грачева Н.М., Шмелева Е.А., Мануйлов Б.М., Эйберман А.С.</copyright-holder><copyright-holder xml:lang="en">Lakhtin V.M., Aleshkin V.A., Lakhtin M.V., Afanas’Iev S.S., Pchelintsev S.Y., Stepanov A.V., Dmitriev G.A., Leontieva N.I., Gracheva N.M., Shmeleva E.A., Manuilov B.M., Eyberman A.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.astmedj.ru/jour/article/view/56">https://www.astmedj.ru/jour/article/view/56</self-uri><abstract><p>Дана оценка технологических перспектив лектинов мукозальных биотопов человека. Защитные лектины действуют как имитаторы клеток защиты, проявляют свойства носителей, доставщиков и распределителей гликополимеров (пребиотиков, лекарств, поверхностных декоров поддержки функционирования клеток, тканей и органов) против инфекций и опухолей. Распознающие синтетические муцинподобные гликополимеры и связывающие их системы лектинов перспективны для конструирования защитных консорциумов синбиотопа. Такие системы лектинов перспективны в качестве лекарственных форм поддержки пациентов. Предложена модель биореактора для оценки пребиотических свойств гликополимеров, лектинов и/или катионов металлов.</p></abstract><trans-abstract xml:lang="en"><p>An evaluation of technological prospects of mucosal lectins of the human mucosal biotope is presented. Protective lectins act as imitators of cells, reveal properties of carriers, deliveries, and distributors of glycopolymers (prebiotics, therapeutics, surface décors supporting functioning cells, tissues and organs) against infections and tumors. The lectin systems recognizing and binding synthetic sets of glycopolymers serve effective instruments for constructing biotope consortia. The model of a minimal bioreactor for testing prebiotic properties of glycopolymers, lectins and/or metal cations is proposed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гликоконъюгаты</kwd><kwd>системы лектинов</kwd><kwd>пробиотики</kwd><kwd>синбиотики</kwd><kwd>мукозальный орган</kwd><kwd>мукозальный иммунитет</kwd><kwd>грамположительные бактерии</kwd><kwd>бифидобактерии</kwd><kwd>лактобациллы</kwd><kwd>дрожжеподобные грибы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>glycoconjugates</kwd><kwd>lectin systems</kwd><kwd>probiotics</kwd><kwd>synbiotics</kwd><kwd>mucosal organ</kwd><kwd>mucosal immunity</kwd><kwd>Gram-positive bacteria</kwd><kwd>bifidobacteria</kwd><kwd>lactobacilli</kwd><kwd>yeast-like fungi</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Лахтин, М. В. Консорциумные и штаммовые пробиотические лектиновые системы мукозального иммунитета против мукозальных инфекций и опухолей : потенциал влияния на микробиоценозы посредством про/синбиотиков / М. В. Лахтин, В. М. Лахтин, С. С. Афанасьев, В. А. Алешкин // Проблемы научной мысли. - 2018. - Т. 12, № 7. - C. 25-44.</mixed-citation><mixed-citation xml:lang="en">Лахтин, М. В. Консорциумные и штаммовые пробиотические лектиновые системы мукозального иммунитета против мукозальных инфекций и опухолей : потенциал влияния на микробиоценозы посредством про/синбиотиков / М. В. Лахтин, В. М. Лахтин, С. С. Афанасьев, В. А. Алешкин // Проблемы научной мысли. - 2018. - Т. 12, № 7. - C. 25-44.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Лахтин, М. В. Пробиотические лектины для инноваций / М. В. Лахтин, В. М. Лахтин, В. А. Алешкин, С. С. 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Aleshkin // Journal of Advances in Biology &amp; Biotechnology (JABB). - 2016. - Vol. 10, № 3. - P. 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Lakhtin, V. Synbiotic minibioreactor regulating by probiotic lectins, metal cations and glycoconjugates / V. Lakhtin, M. Lakhtin, V. Aleshkin // Proceedings of the 19th European Carbohydrate Symposium EUROCARB (2-6 July 2017, Barcelona). Scientific Program and Abstract Book. - Barcelona, 2017. - P. 591.</mixed-citation><mixed-citation xml:lang="en">Lakhtin, V. Synbiotic minibioreactor regulating by probiotic lectins, metal cations and glycoconjugates / V. Lakhtin, M. Lakhtin, V. Aleshkin // Proceedings of the 19th European Carbohydrate Symposium EUROCARB (2-6 July 2017, Barcelona). Scientific Program and Abstract Book. - Barcelona, 2017. - P. 591.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lakhtin, M. V. Metabolite multiprobiotic formulas for microbial health / M. V. Lakhtin, V. M. Lakhtin, V. A. Aleshkin, S. S. Afanasiev // Oral health by using probiotic products. - 2019. - 21 p. doi: 10.5772/intechopen.86449.</mixed-citation><mixed-citation xml:lang="en">Lakhtin, M. V. Metabolite multiprobiotic formulas for microbial health / M. V. Lakhtin, V. M. Lakhtin, V. A. Aleshkin, S. S. Afanasiev // Oral health by using probiotic products. - 2019. - 21 p. doi: 10.5772/intechopen.86449.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
