astmedАстраханский медицинский журналAstrakhan medical journal1992-6499ФГБОУ ВО Астраханский ГМУ Минздрава России10.17021/1992-6499-2024-2-6-13astmed-437Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSНежелательные побочные реакции при введении внутридермальных имплантатов на основе гиалуроновой кислотыUndesirable side reactions when introducing intradermal implants based on hyaluronic acidАрнаудоваК. Ш.ArnaudovaK. Sh.

Кристина Шотаевна Арнаудова, кандидат медицинских наук, ассистент кафедры дерматовенерологии

Астрахань

Kristina Sh. Arnaudova, Cand. Sci. (Med.), Assistant

Astrakhan

arnaudova@mail.ruСароянцЛ. В.SaroyantsL. V.

Людмила Валентиновна Сароянц, доктор медицинских наук, доцент, профессор кафедры клинической фармакологии; профессор кафедры фундаментальной биологии

Астрахань

Lyudmila V. Saroyants, Dr. Sci. (Med.), Associate Professor, Professor of the Department; Professor of the Department

Astrakhan

luda_saroyants@mail.ruАстраханский государственный медицинский университетРоссияAstrakhan State Medical UniversityRussian FederationАстраханский государственный медицинский университет; Астраханский государственный университет имени В. Н. ТатищеваРоссияAstrakhan State Medical University; Astrakhan Tatishev State UniversityRussian Federation202417072024192613Copyright © Арнаудова К.Ш., Сароянц Л.В., 20242024Арнаудова К.Ш., Сароянц Л.В.Arnaudova K.S., Saroyants L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.astmedj.ru/jour/article/view/437

На протяжении последних двух десятилетий наблюдается рост популярности процедур с применением препаратов на основе гиалуроновой кислоты. Параллельно с этим растет количество препаратов с недостаточно очищенной гиалуроновой кислотой, что обусловлено удешевлением продукта, а это приводит к развитию нежелательных побочных реакций. Патогенез некоторых подобных реакций до конца не выяснен, что затрудняет их диагностику и лечение. Рассмотрены виды нежелательных побочных реакций, факторы, влияющие на их развитие, а также варианты их коррекции.

Over the past two decades, there has been an increase in the popularity of procedures using hyaluronic acid-based products. In parallel with this, the number of drugs with insufficiently purified hyaluronic acid is growing, in order to reduce the cost of the product, which leads to the development of unwanted adverse reactions (ADRs). The pathogenesis of some reactions is not fully understood, which makes their diagnosis and treatment difficult. The article discusses the types of NPD, factors influencing their development, as well as options for their correction.

гиалуроновая кислотанежелательные побочные реакциидермальные наполнителииммуногенностьосложненияhyaluronic acidunwanted side reactionsdermal fillersimmunogenicitycomplicationsАвторы декларируют отсутствие внешнего финансирования для проведения исследования и публикации статьи.The authors declare that there is no external funding for the exploration and analysis work.ReferencesRobert L. Hyaluronan, a truly “youthful” polysaccharide. Its medical applications // Pathologie Biologie. 2015. Vol. 63. Р. 32–34. doi: 10.1016/j.patbio.2014.05.019.Robert L. Hyaluronan, a truly “youthful” polysaccharide. Its medical applications. Pathologie Biologie. 2015; 63: 32–34. doi: 10.1016/j.patbio.2014.05.019.Witting M., Boreham A., Brodwolf R., Vávrová K., Alexiev U., Friess W., Hedtrich S. Interactions of hyaluronic acid with the skin and implications for the dermal delivery of biomacromolecules // Molecular Pharmaceutics. 2015. Vol. 12. 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The authors declare that there are no conflicts of interest present.