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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">astmed</journal-id><journal-title-group><journal-title xml:lang="ru">Астраханский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Astrakhan medical journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1992-6499</issn><publisher><publisher-name>ФГБОУ ВО Астраханский ГМУ Минздрава России</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17021/1992-6499-2024-2-69-77</article-id><article-id custom-type="elpub" pub-id-type="custom">astmed-343</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL INVESTIGATIONS</subject></subj-group></article-categories><title-group><article-title>Значение биохимических маркеров повреждения миокарда у пациентов с острым инфарктом миокарда и COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Significance of biochemical markers of myocardial injury in patients with acute myocardial infarction and COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петрова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Владимировна Петрова, доктор медицинских наук, заведующая клинико-диагностической лаборатории</p><p>Астрахань</p></bio><bio xml:lang="en"><p>Ol’ga V. Petrova, Dr. Sci. (Med.), Head of the Laboratory</p><p>Astrakhan</p></bio><email xlink:type="simple">students_asma@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Твердохлебова</surname><given-names>Д. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Tverdokhlebova</surname><given-names>D.  K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Диана Камильевна Твердохлебова, врач клинической лабораторной диагностики</p><p>Астрахань</p></bio><bio xml:lang="en"><p>Diana K. Tverdokhlebova, Physician Clinical Laboratory Diagnostics</p><p>Astrakhan</p></bio><email xlink:type="simple">tverdian@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шашин</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shashin</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергей Александрович Шашин, доктор медицинских наук, доцент, профессор кафедры хирургических болезней стоматологического факультета</p><p>Астрахань</p></bio><bio xml:lang="en"><p>Sergey A. Shashin, Dr. Sci. (Med.), Professor, Professor of the Department</p><p>Astrakhan</p><p> </p></bio><email xlink:type="simple">post@astgmu.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зеньков</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zen’kov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александр Александрович Зеньков, доктор медицинских наук, заведующий кардиохирургическим отделением</p><p>Астрахань</p></bio><bio xml:lang="en"><p>Alexandr A. Zen’kov, Dr. Sci. (Med.), Head of the Department</p><p>Astrakhan</p><p> </p></bio><email xlink:type="simple">tverdian@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернов</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernov</surname><given-names>I. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Игорь Ионович Чернов, кандидат медицинских наук, заместитель главного врача</p><p>Астрахань</p><p> </p></bio><bio xml:lang="en"><p>Igor’ I. Chernov, Cand. Sci. (Med.), Deputy Chief Physician</p><p>Astrakhan</p></bio><email xlink:type="simple">tverdian@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ " Федеральный центр сердечно-сосудистой хирургии"</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Center of Cardiovascular Surgery</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Астраханский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Astrakhan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>15</day><month>07</month><year>2024</year></pub-date><volume>19</volume><issue>2</issue><fpage>69</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Петрова О.В., Твердохлебова Д.К., Шашин С.А., Зеньков А.А., Чернов И.И., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Петрова О.В., Твердохлебова Д.К., Шашин С.А., Зеньков А.А., Чернов И.И.</copyright-holder><copyright-holder xml:lang="en">Petrova O.V., Tverdokhlebova D.K., Shashin S.A., Zen’kov A.A., Chernov I.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.astmedj.ru/jour/article/view/343">https://www.astmedj.ru/jour/article/view/343</self-uri><abstract><p>Клинико-инструментальные данные пациентов с острым инфарктом миокарда для идентификации COVID-19 малоинформативны. Цель –изучить значение маркеров повреждения миокарда при поступлении у пациентов с острым инфарктом миокарда на фоне COVID-19. При поступлении в стационар у 20 пациентов с острым инфарктом миокарда и COVID-19 в крови изучили маркеры повреждения миокарда (высокочувствительный тропонин Т, миоглобин и фракцию МВ креатинкиназы) с помощью иммунохемилюминесцентного метода на иммуноферментном анализаторе “Cobas е 411” (“Roche Diagnostics”, Германия). Значения высокочувствительного тропонина Т у пациентов с острым инфарктом миокарда и COVID-19 были достоверно ниже, чем у пациентов с острым инфарктом миокарда без COVID-19 (94,8 против 171,8 пг/мл). Отсутствовали статистически значимые различия в значениях миоглобина и фракции МВ креатинкиназы в исследуемых группах. Таким образом, маркеры повреждения миокарда у пациентов с острым инфарктом миокарда не имеют предиктивного значения в отношении COVID-19.</p></abstract><trans-abstract xml:lang="en"><p>Clinical and instrumental data of patients with acute myocardial infarction are of little informative value for COVID-19 identification. The aim is to study the significance of myocardial injury markers on admission in patients with acute myocardial infarction on COVID-19 background. At admission to the hospital in 20 patients with acute myocardial infarction and COVID-19 in blood markers of myocardial damage (highly sensitive troponin T, myoglobin and creatine kinase MB fraction) were studied using immunochemiluminescent method on immunoenzyme analyzer “Cobas e 411” (“Roche Diagnostics”, Germany). The values of highly sensitive troponin T in patients with acute myocardial infarction and COVID-19 were significantly lower than in patients with acute myocardial infarction without COVID-19 (94.8 vs. 171.8 pg/ml). There were no statistically significant differences in the values of myoglobin and the MB creatine kinase fraction in the study groups. Thus, markers of myocardial damage in patients with acute myocardial infarction have no predictive value in relation to COVID-19.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>новая коронавирусная инфекция</kwd><kwd>острый инфаркт миокарда</kwd><kwd>маркеры повреждения миокарда</kwd></kwd-group><kwd-group xml:lang="en"><kwd>new coronavirus infection</kwd><kwd>acute myocardial infarction</kwd><kwd>markers of myocardial damage</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Авторы декларируют отсутствие внешнего финансирования для проведения исследования и публикации статьи.</funding-statement><funding-statement xml:lang="en">The authors declare that there is no external funding for the exploration and analysis work.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С. А. 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