astmedАстраханский медицинский журналAstrakhan medical journal1992-6499ФГБОУ ВО Астраханский ГМУ Минздрава России10.17021/1992-6499-2024-4-16-30astmed-329Research ArticleНАУЧНЫЙ ОБЗОРSCIENTIFIC REVIEWSВлияние дисбиоза кишечника на течение расстройств аутистического спектра у детей: обзор литературыInfluence of intestinal dysbiosis on the course of authistic spectrum: literature reviewhttps://orcid.org/0000-0003-4712-3043ГригорьянцЭ. О.GrigoryantsE. O.

Элина Олеговна Григорьянц, старший преподаватель кафедры микробиологии и вирусологии с курсом иммунологии

Тверь

Elina O. Grigoryants, Assistant of the Department microbiology, virology with course of immunology 

Tver

lina.grigi@gmail.comhttps://orcid.org/0000-0001-9209-7839ЧервинецЮ. В.ChervinetsYu. V.

Юлия Вячеславовна Червинец, доктор медицинских наук, профессор, заведующий кафедрой микробиологии и вирусологии с курсом иммунологии

Тверь

Yulia V. Chervinets, Sci. (Med.), Professor, Head of the Department microbiology, virology with course of immunology

Tver

julia_chervinec@mail.ruhttps://orcid.org/0000-0001-5304-1963ЧервинецВ. М.ChervinetsV. M.

Вячеслав Михайлович Червинец, доктор медицинских наук, профессор, профессор кафедры микробиологии и вирусологии с курсом иммунологии

Тверь

Vyacheslav M. Chervinets, Dr. Sci. (Med.), Professor, Professor of the Department microbiology, virology with course of immunology

Tver

chervinets@mail.ruhttps://orcid.org/0000-0002-3870-5765РумянцеваЕ. С.RumyantsevaE. S.

Елизавета Сергеевна Румянцева, ординатор кафедры поликлинической педиатрии и неона

Тверь

Elizaveta S. Rumyantseva, Resident of the Department polyclinic pediatrics and neonatology

Tver

mm.els@yandex.ruТверской государственный медицинский университетРоссияTver State Medical UniversityRussian Federation2024261220241941630Copyright © Григорьянц Э.О., Червинец Ю.В., Червинец В.М., Румянцева Е.С., 20242024Григорьянц Э.О., Червинец Ю.В., Червинец В.М., Румянцева Е.С.Grigoryants E.O., Chervinets Y.V., Chervinets V.M., Rumyantseva E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.astmedj.ru/jour/article/view/329

Представлен обзор исследований, разъясняющих механизмы, с помощью которых кишечная микробиота, ее метаболиты и мозг взаимодействуют, влияя на патогенез и клинику расстройств аутистического спектра. Более глубокое понимание взаимодействий оси «кишечник – мозг» может стать основой для новых методов лечения, направленных на облегчение симптоматики у детей с расстройствами аутистического спектра.

The article presents a review of studies elucidating the mechanisms by which the gut microbiota, its metabolites, and the brain interact to influence the pathogenesis and clinical presentation of autism spectrum disorders. A deeper understanding of gut-brain axis interactions could provide the basis for new therapies aimed at alleviating symptoms in children with autism spectrum disorders.

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The authors declare that there are no conflicts of interest present.