astmedАстраханский медицинский журналAstrakhan medical journal1992-6499ФГБОУ ВО Астраханский ГМУ Минздрава России10.29039/1992-6499-2023-1-27-38astmed-231Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSРоль процессов свободно-радикального окисления в патогенезе невынашивания беременности ранних сроковThe role of free-radical oxidation processes in the pathogenesis of early miscarriageТишковаО. Г.TishkovaO. G.

Ольга Геннадьевна Тишкова, кандидат медицинских наук, доцент

педиатрический факультет с курсом последипломного образования

кафедра акушерства и гинекологии

Астрахань

Olga G. Tishkova, Cand. Sci. (Med.), Associate Professor

Astrakhan

tishkov2003@mail.ruДикареваЛ. В.DikarevaL. V.

Людмила Васильевна Дикарева, доктор медицинских наук, профессор, заведующая кафедрой

педиатрический факультет с курсом последипломного образования

кафедра акушерства и гинекологии

Астрахань

Lyudmila V. Dikareva, Dr. Sci. (Med.), Professor, Head of the Department

Astrakhan

dikarevalv@mail.ruТеплыйД. Д.TepliyD. D.

Дмитрий Давидович Теплый, кандидат биологических наук, старший научный сотрудник

Совместная лаборатория по исследованию роли апоптоза в формировании нейроэндокринной системы

Астрахань

Dmitry D. Tepliy, Dr. Sci. (Biol.), Senior Researcher

Astrakhan

dima.tepliy@yandex.ruАстраханский государственный медицинский университетРоссияAstrakhan State Medical UniversityRussian FederationАстраханский государственный университетРоссияAstrakhan State UniversityRussian Federation2023290420231812738Copyright © Тишкова О.Г., Дикарева Л.В., Теплый Д.Д., 20232023Тишкова О.Г., Дикарева Л.В., Теплый Д.Д.Tishkova O.G., Dikareva L.V., Tepliy D.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.astmedj.ru/jour/article/view/231

   Несмотря на уже известные патогенетические факторы и механизмы невынашивания беременности, около 50 % подобных случаев продолжают оставаться неуточненными или идиопатическими. В последние годы активно обсуждается роль оксидативного стресса в патогенезе развития многих заболеваний, в том числе женской репродуктивной системы и осложнений беременности.

   Цель обзора – проанализировать и предоставить информацию о роли процессов свободно-радикального окисления в развитии и течении беременности как в норме, так и при невынашивании, а также о возможном использовании в практической медицине биомаркеров оксидативного стресса для оценки характера патологического процесса и эффективности проводимого лечения.

   Понимание процессов повреждения клеток, вызванных оксидативным стрессом, может не только оказать неоценимую помощь в разработке персонализированного подхода к каждому конкретному случаю невынашивания беременности, но и расширить как научные, так и клинические знания в этой области медицины.

   Currently, despite the already known pathogenic factors and mechanisms of miscarriage, about 50 % of ones continue to be unspecified or idiopathic. In recent years, the role of oxidative stress in the pathogenesis of many diseases, including the female reproductive system and pregnancy complications, has been actively discussed.

   The purpose of the review is to analyze and provide information on the role of free-radical oxidation processes in the development and course of a pregnancy, both in normal and in miscarriage, as well as on the possible use of oxidative stress biomarkers in practical medicine, in order to assess the nature of the pathological process and the effectiveness of treatment.

   Understanding the processes of cell damage caused by oxidative stress can provide invaluable assistance not only in developing a personalized approach to each specific case of miscarriage, but also to expand knowledge, both scientific and clinical in this area of medicine.

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The authors declare that there are no conflicts of interest present.