astmedАстраханский медицинский журналAstrakhan medical journal1992-6499ФГБОУ ВО Астраханский ГМУ Минздрава России10.48612/agmu/2022.17.2.21.28astmed-160Research ArticleНАУЧНЫЕ ОБЗОРЫSCIENTIFIC REVIEWSРАЗНООБРАЗИЕ МИКРОФЛОРЫ ЖЕЛУДКА: РОЛЬ В НОРМЕ И ПАТОЛОГИИSCIENTIFIC REVIEWS Review article GASTRIC MICROBIOME DIVERSITY IN HEALTH AND DISEASEТерещенкоВ. С.TereshchenkoV. S.basterser@yandex.ruЖестковА. В.ZhestkovA. V.avzhestkov2015@yandex.ruЖелезноваЕ. А.ZheleznovaE. A.elena9446@mail.ruСавиноваТ. А.SavinovaT. A.taniasavinova@gmail.comЛяминА. В.LyaminA. V.avlyamin@rambler.ruСамарский государственный медицинский университеРоссияSamara State Medical UniversityRussian FederationРоссийский национальный исследовательский медицинский университет имени Н. И. ПироговаРоссияPirogov Russian National Research Medical UniversityRussian Federation2022270220231722128Copyright © Терещенко В.С., Жестков А.В., Железнова Е.А., Савинова Т.А., Лямин А.В., 20232023Терещенко В.С., Жестков А.В., Железнова Е.А., Савинова Т.А., Лямин А.В.Tereshchenko V.S., Zhestkov A.V., Zheleznova E.A., Savinova T.A., Lyamin A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.astmedj.ru/jour/article/view/160

Приведены современные представления о желудочном микробиоме. Описаны наиболее часто встречающиеся в желудке микроорганизмы, включая представителей Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria и Fusobacteria. Показана связь орофарингеального и дуоденального экотопов с желудком. Рассмотрено влияние таких патологий, как гастрит, метаплазия желудочного эпителия и рака желудка, а также воздействие ингибиторов протонной помпы и пробиотиков на сдвиги в качественном и количественном составе микрофлоры желудка.

This review article presents the current understanding of the gastric microbiome. The most common microorganisms found in the stomach are described, including the representatives of Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria and Fusobacteria. The relationship of the oropharyngeal and duodenal ecotopes to the stomach is shown. The influence of various diseases such as gastritis, gastric epithelium metaplasia and gastric cancer, as well as the effect of proton pump inhibitors and probiotics on shifts in the qualitative and quantitative composition of gastric microflora is described.

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The authors declare that there are no conflicts of interest present.